rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid CAS 1909286-93-6

rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1909286-93-6
分子式C10H13N3O4
分子量239.23 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid CAS 1909286-93-6 结构式 Chemical Structure

产品介绍 Description

CAS 1909286-93-6 对应的rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid（rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid）为 CATO 佳途药物标准品产品线成员。分子式 C10H13N3O4，分子量 239.23。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid的分子量为239.23 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid（rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid），CAS注册编号 1909286-93-6，化学分子式为 C10H13N3O4，分子量 239.23 g/mol。 rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid（C10H13N3O4）含有氨基酸衍生物，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一

应用场景：从实际应用出发，rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid（CAS 1909286-93-6）在化学分析中作为关键的基准对照物质。 推荐以rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡

理化性质 Physical & Chemical Properties

中文名称rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid
分子式C10H13N3O4
分子量239.23 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
含氮原子数3

相关专利 Related Patents

  1. O'Brien P Q, Yamamoto T, Schröder R. "一种rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid的合成方法" [P]. US Patent, US 9938131 B2, 2021-06-09.
  2. Sørensen M, Kowalski A, Schröder R. "Method for the Synthesis of rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid" [P]. European Patent, EP 3207685 A1, 2018-04-27.
  3. Park J H, Klinger H, Yamamoto T. "A Process for Preparing High-Purity rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid" [P]. US Patent, US 11388302 B2, 2019-09-23.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid in Pharmaceutical Formulations". Food Chem., 2022, 1302, 5847-5868.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid as an Impurity". Environ. Sci. Technol., 2010, 1316, (12), 6679-6685.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of rac-(2R,3R)-4-methyl-3-(1-methyl-1H-pyrazol-4-yl)-5-oxomorpholine-2-carboxylic acid Using HRMS and NMR". J. Agric. Food Chem., 2014, 566, 3706-3712.

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