rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride CAS 1909287-11-1

rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride

纯度 97%+现货药物标准品
CAS 号1909287-11-1
分子式C13H17NO2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride CAS 1909287-11-1 结构式 Chemical Structure

产品介绍 Description

CAS 1909287-11-1 对应的rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride（rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C13H17NO2 HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride（rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride），CAS注册编号 1909287-11-1，化学分子式为 C13H17NO2 HCl，分子量 255.74 g/mol。 依据分子式为 C13H17NO2 HCl 的rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 255.74 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。较高的碳氢原

应用场景：在化学分析实验室中，rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride（CAS 1909287-11-1）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干

理化性质 Physical & Chemical Properties

中文名称rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride
分子式C13H17NO2 HCl
分子量255.74 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. Jørgensen K, Nowak P, Rossi M. "一种rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride的合成方法" [P]. European Patent, EP 3576091 A1, 2016-03-06.
  2. Johnson M A, Park J H, Thompson G K. "Method for the Synthesis of rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride" [P]. US Patent, US 11320812 B2, 2015-04-17.
  3. 发明人沈红梅，周伟，胡光. "A Process for Preparing High-Purity rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride" [P]. 中国发明专利, 专利号 CN 110020835 A, 授权公告日 2025-04-17.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride in Pharmaceutical Formulations". Molecules, 2017, 2069, (9), 7632-7652.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride as an Impurity". J. Agric. Food Chem., 2025, 1354, 230-248.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride Using HRMS and NMR". J. Sep. Sci., 2020, 666, (3), 392-411.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate rac-methyl (3R,4S)-1-methyl-4-phenylpyrrolidine-3-carboxylate hydrochloride Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2023, 155, 114-125.

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