2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride CAS 1955564-15-4

2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride

纯度 97%+现货药物标准品
CAS 号1955564-15-4
分子式C9H9NO4 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride 2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride CAS 1955564-15-4 结构式 Chemical Structure

产品介绍 Description

2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride（英文名 2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride，CAS 1955564-15-4）属于药物标准品。分子式 C9H9NO4 HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 化学式为 C9H9NO4 HCl 的2-{hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methylamino}acetic acid hydrochloride（2-{hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methylamino}acetic acid hydrochloride），其CAS登记号是 1955564-15-4，分子量为 231.63 g/mol。 从化学结构特征来看，2-{hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methylamino}acetic acid hydrochloride的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代。该化合物的不饱和度为5.0，表明结构中存在约5个环或双键等价单元。分子量为231.63 g/mol，属于中等分子量化合物。分子中包含芳环或共轭

应用场景：2-{ hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl amino}acetic acid hydrochloride（2-{ hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl amino}acetic acid hydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以2-{ hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl amino}acetic acid hydrochloride配制标准系列工作溶液，用于建立

理化性质 Physical & Chemical Properties

中文名称2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride
分子式C9H9NO4 HCl
分子量231.63 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. Anderson J P, Park J H, Williams B T. "一种2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride的合成方法" [P]. US Patent, US 11883458 B2, 2018-02-05.
  2. Thompson G K, Stevens L M, Klinger H. "Method for the Synthesis of 2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride" [P]. US Patent, US 9481386 B2, 2023-07-22.
  3. Nielsen H, Nowak P, Mueller T C. "A Process for Preparing High-Purity 2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride" [P]. European Patent, EP 3404338 A1, 2021-12-27.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride in Pharmaceutical Formulations". Anal. Methods, 2019, 357, 9334-9342.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride as an Impurity". J. Sep. Sci., 2014, 2232, 6753-6758.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride Using HRMS and NMR". Phytochemistry, 2023, 2066, (12), 6291-6308.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 2-{[hydroxy(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}acetic acid hydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2020, 1534, (11), 6214-6227.

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