rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride CAS 1969288-15-0

rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride

纯度 97%+现货药物标准品
CAS 号1969288-15-0
分子式C9H13N3O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride CAS 1969288-15-0 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride（rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride）为药物标准品，CAS 登记号 1969288-15-0，分子式 C9H13N3O2 HCl。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride（rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride），CAS注册编号 1969288-15-0，化学分子式为 C9H13N3O2 HCl，分子量 231.68 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代的影响，rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride表现为类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）。其固体形态的物理化学属性——包括231.68 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。由于结构中存在共轭发色团，该化合物在200-400 nm区间具有显著的紫外吸收，便于HPLC-UV检测。

应用场景：rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride（rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride，CAS 1969288-15-0）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride配制标

理化性质 Physical & Chemical Properties

中文名称rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride
分子式C9H13N3O2 HCl
分子量231.68 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人韩伟，郭海燕，林芳. "一种rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 113945160 A, 授权公告日 2022-05-19.
  2. Jørgensen K, Martínez F, Nielsen H. "Method for the Synthesis of rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride" [P]. European Patent, EP 3357727 A1, 2021-07-03.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride in Pharmaceutical Formulations". Biomed. Chromatogr., 2019, 1883, 4061-4077.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride as an Impurity". Chemosphere, 2019, 2095, (8), 9586-9613.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride Using HRMS and NMR". J. Agric. Food Chem., 2010, 2133, (3), 9229-9253.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate rac-(3R,4S)-4-(1-methyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2014, 1523, (6), 7490-7510.

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