rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol CAS 1969288-14-9

rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol

纯度 97%+现货药物标准品
CAS 号1969288-14-9
分子式C13H21N3O
分子量235.33 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol CAS 1969288-14-9 结构式 Chemical Structure

产品介绍 Description

rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol（英文名 rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol，CAS 1969288-14-9）属于药物标准品。分子式 C13H21N3O，分子量 235.33。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

化学式为 C13H21N3O 的rac-(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-ylmethanol（rac-(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-ylmethanol），其CAS登记号是 1969288-14-9，分子量为 235.33 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键的影响，rac-(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-ylmethanol表现为类白色至淡黄色低熔点固体。其固体形态的物理化学属性——包括235.33 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。由于碳链较长，脂溶性良好，该化合物在Octanol-Water分配系数测试中倾向于有机相。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标

应用场景：rac- (2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl methanol（rac- (2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl methanol，CAS 1969288-14-9）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以rac- (2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl methanol配制标准系列工作溶液，用于建立

理化性质 Physical & Chemical Properties

中文名称rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol
分子式C13H21N3O
分子量235.33 g/mol
外观形态类白色至淡黄色低熔点固体
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
含氮原子数3

相关专利 Related Patents

  1. 发明人朱建伟，胡光，张德明. "一种rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol的合成方法" [P]. 中国发明专利, 专利号 CN 113019437 B, 授权公告日 2022-02-28.
  2. Mueller T, Hughes D C, Roberts E F. "Method for the Synthesis of rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol" [P]. US Patent, US 10183181 B2, 2015-01-21.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol in Pharmaceutical Formulations". Molecules, 2023, 1553, 5825-5831.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol as an Impurity". Biomed. Chromatogr., 2011, 2197, (5), 4362-4384.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of rac-[(2R,3R)-1-cyclopropyl-2-(1-methyl-1H-imidazol-5-yl)piperidin-3-yl]methanol Using HRMS and NMR". Sci. Total Environ., 2019, 2328, 4408-4418.

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