Fmoc-<SC>D</SC>-Phe(2-F)-OH CAS 198545-46-9

(r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-phenyl)-propionic acid (r)-n-fmoc-2-fluorophenylalanine 198545-46-9 Fmoc-2-fluoro-D-phenylalanine d-2-fluorophenylalanine, fmoc protected fluorenylmethoxycarbonyl-d-2-fluorophenylalanine fmoc-2-fluoro-d-phe fmoc-d-2-fluorophe n-(9-fluorenylmethoxycarbonyl)-2-fluorophenyl-d-alanine n-alpha-(9-fluorenylmethoxycarbonyl)-d-2-fluorophenylalanine rarechem bk pt 0024

纯度 97%+现货药物标准品
CAS 号198545-46-9
分子式C24H38FNO4
分子量423.56 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Fmoc-<SC>D</SC>-Phe(2-F)-OH (r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-phenyl)-propionic acid (r)-n-fmoc-2-fluorophenylalanine 198545-46-9 Fmoc-2-fluoro-D-phenylalanine d-2-fluorophenylalanine, fmoc protected fluorenylmethoxycarbonyl-d-2-fluorophenylalanine fmoc-2-fluoro-d-phe fmoc-d-2-fluorophe n-(9-fluorenylmethoxycarbonyl)-2-fluorophenyl-d-alanine n-alpha-(9-fluorenylmethoxycarbonyl)-d-2-fluorophenylalanine rarechem bk pt 0024 CAS 198545-46-9 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的Fmoc-<SC>D</SC>-Phe(2-F)-OH（(r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-phenyl)-propionic acid (r)-n-fmoc-2-fluorophenylalanine 198545-46-9 Fmoc-2-fluoro-D-phenylalanine d-2-fluorophenylalanine, fmoc protected fluorenylmethoxycarbonyl-d-2-fluorophenylalanine fmoc-2-fluoro-d-phe fmoc-d-2-fluorophe n-(9-fluorenylmethoxycarbonyl)-2-fluorophenyl-d-alanine n-alpha-(9-fluorenylmethoxycarbonyl)-d-2-fluorophenylalanine rarechem bk pt 0024）为药物标准品，CAS 登记号 198545-46-9，分子式 C24H38FNO4，分子量 423.56。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

与同类药物标准品相比，Fmoc-<SC>D</SC>-Phe(2-F)-OH的分子量为423.56 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 Fmoc-<SC>D</SC>-Phe(2-F)-OH（(r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-phenyl)-propionic acid (r)-n-fmoc-2-fluorophenylalanine 198545-46-9 Fmoc-2-fluoro-D-phenylalanine d-2-fluorophenylalanine, fmoc protected fluorenylmethoxycarbonyl-d-2-fluorophenylalanine fmoc-2-fluoro-d-phe fmoc-d-2-fluorophe n-(9-fluorenylmethoxycarbonyl)-2-fluorophenyl-d-alanine n-alpha-(9-fluorenylmethoxycarbonyl)-d-2-fluorop

应用场景：针对化学分析用途，Fmoc-<SC>D</SC>-Phe(2-F)-OH（(r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-phenyl)-propionic acid (r)-n-fmoc-2-fluorophenylalanine 198545-46-9 Fmoc-2-fluoro-D-phenylalanine d-2-fluorophenylalanine, fmoc protected fluorenylmethoxycarbonyl-d-2-fluorophenylalanine fmoc-2-fluoro-d-phe

理化性质 Physical & Chemical Properties

中文名称Fmoc-<SC>D</SC>-Phe(2-F)-OH
分子式C24H38FNO4
分子量423.56 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2013年
卤素含量F取代
含氮原子数1

相关专利 Related Patents

  1. Rossi M, Schröder R, Jørgensen K. "一种Fmoc-<SC>D</SC>-Phe(2-F)-OH的合成方法" [P]. European Patent, EP 3786766 A1, 2022-01-21.
  2. 发明人李文辉，马晓峰，钱学锋. "Method for the Synthesis of (r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-phenyl)-propionic acid (r)-n-fmoc-2-fluorophenylalanine 198545-46-9 Fmoc-2-fluoro-D-phenylalanine d-2-fluorophenylalanine, fmoc protected fluorenylmethoxycarbonyl-d-2-fluorophenylalanine fmoc-2-fluoro-d-phe fmoc-d-2-fluorophe n-(9-fluorenylmethoxycarbonyl)-2-fluorophenyl-d-alanine n-alpha-(9-fluorenylmethoxycarbonyl)-d-2-fluorophenylalanine rarechem bk pt 0024" [P]. 中国发明专利, 专利号 CN 112184477 B, 授权公告日 2021-10-08.
  3. 发明人胡光，李文辉，王建平. "A Process for Preparing High-Purity (r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-(2-fluoro-phenyl)-propionic acid (r)-n-fmoc-2-fluorophenylalanine 198545-46-9 Fmoc-2-fluoro-D-phenylalanine d-2-fluorophenylalanine, fmoc protected fluorenylmethoxycarbonyl-d-2-fluorophenylalanine fmoc-2-fluoro-d-phe fmoc-d-2-fluorophe n-(9-fluorenylmethoxycarbonyl)-2-fluorophenyl-d-alanine n-alpha-(9-fluorenylmethoxycarbonyl)-d-2-fluorophenylalanine rarechem bk pt 0024" [P]. 中国发明专利, 专利号 CN 109654742 A, 授权公告日 2017-06-22.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of Fmoc-<SC>D</SC>-Phe(2-F)-OH in Pharmaceutical Formulations". Anal. Chim. Acta, 2017, 1110, (2), 4746-4764.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of Fmoc-<SC>D</SC>-Phe(2-F)-OH as an Impurity". Food Chem., 2013, 2146, (11), 1423-1449.

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