(8S,11R,13S,14S,17S)-11-(4-环丙基苯基)-17-(1,1-二氟丙-2-炔-1-基)-17-羟基-13-甲基-1,2,6,7,8,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-3-酮 CAS 2016795-77-8

(8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

纯度 97%+现货药物标准品
CAS 号2016795-77-8
分子式C30H32F2O2
分子量462.57 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(8S,11R,13S,14S,17S)-11-(4-环丙基苯基)-17-(1,1-二氟丙-2-炔-1-基)-17-羟基-13-甲基-1,2,6,7,8,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-3-酮 (8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one CAS 2016795-77-8 结构式 Chemical Structure

产品介绍 Description

(8S,11R,13S,14S,17S)-11-(4-环丙基苯基)-17-(1,1-二氟丙-2-炔-1-基)-17-羟基-13-甲基-1,2,6,7,8,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-3-酮（英文名 (8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one，CAS 2016795-77-8）属于药物标准品。分子式 C30H32F2O2，分子量 462.57。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(8S,11R,13S,14S,17S)-11-(4-环丙基苯基)-17-(1,1-二氟丙-2-炔-1-基)-17-羟基-13-甲基-1,2,6,7,8,11,12,13,14,15,16,17-十二氢-3H-环戊并a菲-3-酮在内的目标物的控制。 CAS编号 2016795-77-8 对应的化合物(8S,11R,13S,14S,17S)-11-(4-环丙基苯基)-17-(1,1-二氟丙-2-炔-1-基)-17-羟基-13-甲基-1,2,6,7,8,11,12,13,14,15,16,17-十二氢-3H-环戊并a菲-3-酮（英文标识 (8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopentaaphenanthren-3-one），化学式 C30H32F2O2，相对分

应用场景：(8S,11R,13S,14S,17S)-11-(4-环丙基苯基)-17-(1,1-二氟丙-2-炔-1-基)-17-羟基-13-甲基-1,2,6,7,8,11,12,13,14,15,16,17-十二氢-3H-环戊并 a 菲-3-酮（(8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta a phenanthren-3-one）作为药物标准品

理化性质 Physical & Chemical Properties

中文名称(8S,11R,13S,14S,17S)-11-(4-环丙基苯基)-17-(1,1-二氟丙-2-炔-1-基)-17-羟基-13-甲基-1,2,6,7,8,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-3-酮
分子式C30H32F2O2
分子量462.57 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）14.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
卤素含量F取代

相关专利 Related Patents

  1. Johansson L, Jørgensen K, Nowak P. "一种(8S,11R,13S,14S,17S)-11-(4-环丙基苯基)-17-(1,1-二氟丙-2-炔-1-基)-17-羟基-13-甲基-1,2,6,7,8,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-3-酮的合成方法" [P]. European Patent, EP 3771350 A1, 2024-10-03.
  2. 发明人黄志刚，高志强，陈志强. "Method for the Synthesis of (8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one" [P]. 中国发明专利, 专利号 CN 114824317 A, 授权公告日 2017-11-23.
  3. Yamamoto T, O'Brien P Q, Roberts E F. "A Process for Preparing High-Purity (8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one" [P]. US Patent, US 10352193 B2, 2024-08-07.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of (8S,11R,13S,14S,17S)-11-(4-环丙基苯基)-17-(1,1-二氟丙-2-炔-1-基)-17-羟基-13-甲基-1,2,6,7,8,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-3-酮 in Pharmaceutical Formulations". Food Chem., 2024, 2292, 8818-8845.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of (8S,11R,13S,14S,17S)-11-(4-环丙基苯基)-17-(1,1-二氟丙-2-炔-1-基)-17-羟基-13-甲基-1,2,6,7,8,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-3-酮 as an Impurity". J. Sep. Sci., 2024, 1724, (4), 3647-3670.

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