rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride CAS 2031242-20-1

rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride

纯度 97%+现货药物标准品
CAS 号2031242-20-1
分子式C12H12F3NO2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride CAS 2031242-20-1 结构式 Chemical Structure

产品介绍 Description

CAS 2031242-20-1 对应的rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride（rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C12H12F3NO2 HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride在内的目标物的控制。 化学式为 C12H12F3NO2 HCl 的rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride（rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride），其CAS登记号是 2031242-20-1，分子量为 295.69 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代的影响，rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride表现为类白色至淡黄色结晶性粉末。（具有轻微卤代物

应用场景：从实际应用出发，rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride（CAS 2031242-20-1）在化学分析中作为关键的基准对照物质。 推荐以rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样

理化性质 Physical & Chemical Properties

中文名称rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride
分子式C12H12F3NO2 HCl
分子量295.69 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
卤素含量F/Cl取代
含氮原子数1

相关专利 Related Patents

  1. Lee S K, Hughes D C, Roberts E F. "一种rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride的合成方法" [P]. US Patent, US 11016534 B2, 2021-05-26.
  2. 发明人冯建国，黄志刚，朱建伟. "Method for the Synthesis of rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride" [P]. 中国发明专利, 专利号 CN 109227590 A, 授权公告日 2023-07-02.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride in Pharmaceutical Formulations". Talanta, 2018, 1522, (4), 8750-8761.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride as an Impurity". Anal. Methods, 2011, 272, 4265-4273.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride Using HRMS and NMR". J. Pharm. Biomed. Anal., 2017, 102, 3990-3993.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate rac-(3R,4S)-4-phenyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2017, 141, (8), 2421-2451.

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