rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one CAS 2031242-78-9

rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one

纯度 97%+现货药物标准品
CAS 号2031242-78-9
分子式C13H20N4O
分子量248.32 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one CAS 2031242-78-9 结构式 Chemical Structure

产品介绍 Description

rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one（rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one）是药物分析与质量控制领域常用的药物标准品，CAS 号 2031242-78-9。分子式 C13H20N4O，分子量 248.32。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one的分子量为248.32 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C13H20N4O 的rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one（rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one），其CAS登记号是 2031242-78-9，分子量为 248.32 g/mol。 rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one（分子式 C13H20N4O）的化学结构中包含含氮杂环结构，酰胺类，含羟

应用场景：针对化学分析用途，rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one（rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one）是具有明确定量溯源的认证级对照品。 推荐以rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one配制标准系列工作溶

理化性质 Physical & Chemical Properties

中文名称rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one
分子式C13H20N4O
分子量248.32 g/mol
外观形态类白色至淡黄色低熔点固体
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1996年
含氮原子数4

相关专利 Related Patents

  1. 发明人李文辉，孙丽萍，周伟. "一种rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one的合成方法" [P]. 中国发明专利, 专利号 CN 110191222 B, 授权公告日 2017-02-10.
  2. 发明人郭海燕，沈红梅，马晓峰. "Method for the Synthesis of rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one" [P]. 中国发明专利, 专利号 CN 115617516 A, 授权公告日 2024-10-15.
  3. Björnsson E, Mueller T C, Nowak P. "A Process for Preparing High-Purity rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one" [P]. European Patent, EP 3262511 A1, 2018-04-12.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one in Pharmaceutical Formulations". Food Chem., 2022, 887, 2387-2396.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one as an Impurity". Environ. Sci. Technol., 2023, 1867, (1), 6422-6429.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one Using HRMS and NMR". Talanta, 2011, 843, (4), 8934-8947.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate rac-(5R,6S)-5-(aminomethyl)-1-cyclopropyl-6-(1-methyl-1H-imidazol-2-yl)piperidin-2-one Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2022, 2213, (10), 3686-3714.

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