rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride CAS 2031242-77-8

rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride

纯度 97%+现货药物标准品
CAS 号2031242-77-8
分子式C8H13F3N2O HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride CAS 2031242-77-8 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride（rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride）为药物标准品，CAS 登记号 2031242-77-8，分子式 C8H13F3N2O HCl。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

与同类药物标准品相比，rac-2,2,2-trifluoro-N-(3R,4R)-4-methylpiperidin-3-ylacetamide hydrochloride的分子量为246.66 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 2031242-77-8 对应的化合物rac-2,2,2-trifluoro-N-(3R,4R)-4-methylpiperidin-3-ylacetamide hydrochloride（英文标识 rac-2,2,2-trifluoro-N-(3R,4R)-4-methylpiperidin-3-ylacetamide hydrochloride），化学式 C8H13F3N2O HCl，相对分子质量 246.66。 受分子结构中酰胺类，含羟基，含醚键，含氟/氯取代的影响，rac-2,2,2-trifluoro-N-(3R,4R)-4-methylpiperidin-3-ylacetamide hydrochloride表现为白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气

应用场景：针对化学分析用途，rac-2,2,2-trifluoro-N- (3R,4R)-4-methylpiperidin-3-yl acetamide hydrochloride（rac-2,2,2-trifluoro-N- (3R,4R)-4-methylpiperidin-3-yl acetamide hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以rac-2,2,2-trifluoro-N- (3R,4R)-4-methylpiperidin-3-yl acetamide hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙

理化性质 Physical & Chemical Properties

中文名称rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride
分子式C8H13F3N2O HCl
分子量246.66 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1996年
卤素含量F/Cl取代
含氮原子数2

相关专利 Related Patents

  1. O'Brien P Q, Thompson G K, Mueller T. "一种rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride的合成方法" [P]. US Patent, US 11371942 B2, 2017-05-19.
  2. Mueller T C, Jørgensen K, Rossi M. "Method for the Synthesis of rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride" [P]. European Patent, EP 3734736 A1, 2016-09-01.
  3. Lee S K, Davis P L, Hughes D C. "A Process for Preparing High-Purity rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride" [P]. US Patent, US 10079526 B2, 2023-04-11.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride in Pharmaceutical Formulations". Biomed. Chromatogr., 2013, 1455, 933-956.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride as an Impurity". J. Pharm. Biomed. Anal., 2015, 2317, 8323-8326.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride Using HRMS and NMR". Chromatographia, 2018, 1548, (7), 889-913.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate rac-2,2,2-trifluoro-N-[(3R,4R)-4-methylpiperidin-3-yl]acetamide hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2021, 1955, (3), 6946-6971.

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