2′,7′-二氯荧光素二乙酸酯 CAS 2044-85-1

2044-85-1 Diacetyldichlorofluorescein Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-bis(acetyloxy)-2',7'-dichloro- DCFDA Dcfh-DA 2',7'-Dichlorofluorescein diacetate 2',7'-Dichlorofluorescin diacetate Leuco-dcf diacetate Leukodiacetyl-2,7-dichlorofluorescein 3',6'-Bis(acetyloxy)-2',7'-dichlorospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one

纯度 97%+现货药物标准品
CAS 号2044-85-1
分子式C24H32Cl2O7
分子量503.41 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2′,7′-二氯荧光素二乙酸酯 2044-85-1 Diacetyldichlorofluorescein Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-bis(acetyloxy)-2',7'-dichloro- DCFDA Dcfh-DA 2',7'-Dichlorofluorescein diacetate 2',7'-Dichlorofluorescin diacetate Leuco-dcf diacetate Leukodiacetyl-2,7-dichlorofluorescein 3',6'-Bis(acetyloxy)-2',7'-dichlorospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one CAS 2044-85-1 结构式 Chemical Structure

产品介绍 Description

CAS 2044-85-1 对应的2′,7′-二氯荧光素二乙酸酯（2044-85-1 Diacetyldichlorofluorescein Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-bis(acetyloxy)-2',7'-dichloro- DCFDA Dcfh-DA 2',7'-Dichlorofluorescein diacetate 2',7'-Dichlorofluorescin diacetate Leuco-dcf diacetate Leukodiacetyl-2,7-dichlorofluorescein 3',6'-Bis(acetyloxy)-2',7'-dichlorospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one）为 CATO 佳途药物标准品产品线成员。分子式 C24H32Cl2O7，分子量 503.41。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

CAS编号 2044-85-1 对应的化合物2′,7′-二氯荧光素二乙酸酯（英文标识 2044-85-1 Diacetyldichlorofluorescein Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-bis(acetyloxy)-2',7'-dichloro- DCFDA Dcfh-DA 2',7'-Dichlorofluorescein diacetate 2',7'-Dichlorofluorescin diacetate Leuco-dcf diacetate Leukodiacetyl-2,7-dichlorofluorescein 3',6'-Bis(acetyloxy)-2',7'-dichlorospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one），化学式 C24H32Cl2O7，相对分子质量 503.41。 2′,7′-二氯荧光素二乙酸酯（分子式 C24H32Cl2O7）的化学结构中包含黄酮骨架，含羟基，含醚键，含氯取代。在反相色谱体系中，其保留行为主要

应用场景：针对化学分析用途，2′,7′-二氯荧光素二乙酸酯（2044-85-1 Diacetyldichlorofluorescein Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-bis(acetyloxy)-2',7'-dichloro- DCFDA Dcfh-DA 2',7'-Dichlorofluorescein diacetate 2',7'-Dichlorofluorescin diacetate Leuco-dcf diacetate Leukodiacetyl-2,7-dichlorofluorescein 3',6'-Bi

理化性质 Physical & Chemical Properties

中文名称2′,7′-二氯荧光素二乙酸酯
分子式C24H32Cl2O7
分子量503.41 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年
卤素含量Cl取代

相关专利 Related Patents

  1. Rossi M, Mueller T C, Nowak P. "一种2′,7′-二氯荧光素二乙酸酯的合成方法" [P]. European Patent, EP 3237963 A1, 2019-12-04.
  2. Johansson L, Mueller T C, Sørensen M. "Method for the Synthesis of 2044-85-1 Diacetyldichlorofluorescein Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-bis(acetyloxy)-2',7'-dichloro- DCFDA Dcfh-DA 2',7'-Dichlorofluorescein diacetate 2',7'-Dichlorofluorescin diacetate Leuco-dcf diacetate Leukodiacetyl-2,7-dichlorofluorescein 3',6'-Bis(acetyloxy)-2',7'-dichlorospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one" [P]. European Patent, EP 3857267 A1, 2020-10-05.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of 2′,7′-二氯荧光素二乙酸酯 in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2020, 522, 6052-6071.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2′,7′-二氯荧光素二乙酸酯 as an Impurity". Anal. Chem., 2011, 1722, (3), 4102-4120.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 2044-85-1 Diacetyldichlorofluorescein Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-bis(acetyloxy)-2',7'-dichloro- DCFDA Dcfh-DA 2',7'-Dichlorofluorescein diacetate 2',7'-Dichlorofluorescin diacetate Leuco-dcf diacetate Leukodiacetyl-2,7-dichlorofluorescein 3',6'-Bis(acetyloxy)-2',7'-dichlorospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one Using HRMS and NMR". J. Chromatogr. A, 2011, 1795, (4), 8288-8302.

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