rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride CAS 2044705-58-8

rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride

纯度 97%+现货药物标准品
CAS 号2044705-58-8
分子式C11H17N3O 3*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride CAS 2044705-58-8 结构式 Chemical Structure

产品介绍 Description

CAS 2044705-58-8 对应的rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride（rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C11H17N3O 3*HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

作为认证标准物质（CRM），rac-(3R,4R)-4-{methyl(pyridin-4-yl)methylamino}pyrrolidin-3-ol trihydrochloride满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 rac-(3R,4R)-4-{methyl(pyridin-4-yl)methylamino}pyrrolidin-3-ol trihydrochloride（rac-(3R,4R)-4-{methyl(pyridin-4-yl)methylamino}pyrrolidin-3-ol trihydrochloride），CAS注册编号 2044705-58-8，化学分子式为 C11H17N3O 3HCl，分子量 243.73 g/mol。 依据分子式为 C11H17N3O 3HCl 的rac-(3R,4R)-4-{methyl(pyridin-4-yl)methylamino}pyrrolid

应用场景：rac-(3R,4R)-4-{methyl (pyridin-4-yl)methyl amino}pyrrolidin-3-ol trihydrochloride（rac-(3R,4R)-4-{methyl (pyridin-4-yl)methyl amino}pyrrolidin-3-ol trihydrochloride，CAS 2044705-58-8）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以rac-(3R,4R)-4-{methyl (pyridin-4-yl)methyl amino}pyrrolidin-3-ol trihydrochloride配制标准系列工作溶

理化性质 Physical & Chemical Properties

中文名称rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride
分子式C11H17N3O 3*HCl
分子量243.73 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人胡光，韩伟，唐晓军. "一种rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 116267235 A, 授权公告日 2022-07-28.
  2. 发明人罗永刚，张德明，徐明华. "Method for the Synthesis of rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride" [P]. 中国发明专利, 专利号 CN 114461906 A, 授权公告日 2017-11-22.
  3. 发明人张德明，徐明华，刘建华. "A Process for Preparing High-Purity rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride" [P]. 中国发明专利, 专利号 CN 116767926 B, 授权公告日 2018-08-07.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride in Pharmaceutical Formulations". Anal. Chim. Acta, 2024, 2082, (9), 5577-5589.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride as an Impurity". Sci. Total Environ., 2012, 1277, (6), 8795-8812.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride Using HRMS and NMR". J. Sep. Sci., 2012, 2284, (7), 9049-9071.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate rac-(3R,4R)-4-{methyl[(pyridin-4-yl)methyl]amino}pyrrolidin-3-ol trihydrochloride Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2017, 1855, (12), 9310-9338.

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