45-(11,12-二脱氢二苯并[b,f]环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯 CAS 2055022-06-3

45-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-41,45-dioxo-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxa-2,42-diazapentatetracontanoic acid (4E)-4-cycloocten-1-yl ester

纯度 97%+现货药物标准品
CAS 号2055022-06-3
分子式C54H81N3O16
分子量1028.23 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

45-(11,12-二脱氢二苯并[b,f]环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯 45-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-41,45-dioxo-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxa-2,42-diazapentatetracontanoic acid (4E)-4-cycloocten-1-yl ester CAS 2055022-06-3 结构式 Chemical Structure

产品介绍 Description

CAS 2055022-06-3 对应的45-(11,12-二脱氢二苯并[b,f]环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯（45-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-41,45-dioxo-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxa-2,42-diazapentatetracontanoic acid (4E)-4-cycloocten-1-yl ester）为 CATO 佳途药物标准品产品线成员。分子式 C54H81N3O16，分子量 1028.23。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在质量保证方面，45-(11,12-二脱氢二苯并b,f环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C54H81N3O16 的45-(11,12-二脱氢二苯并b,f环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯（45-(11,12-Didehydrodibenzb,fazocin-5(6H)-yl)-41,45-dioxo-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxa-2,42-diazapentatetracontanoic ac

应用场景：针对化学分析用途，45-(11,12-二脱氢二苯并 b,f 环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯（45-(11,12-Didehydrodibenz b,f azocin-5(6H)-yl)-41,45-dioxo-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxa-2,42-diazapentatetracontanoic acid (4E)-4-cycloocten-1-yl ester）是具有明确定量溯源的认证级对照品。 推荐以

理化性质 Physical & Chemical Properties

中文名称45-(11,12-二脱氢二苯并[b,f]环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯
分子式C54H81N3O16
分子量1028.23 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）16.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
含氮原子数3

相关专利 Related Patents

  1. 发明人周伟，赵玉洁，钱学锋. "一种45-(11,12-二脱氢二苯并[b,f]环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯的合成方法" [P]. 中国发明专利, 专利号 CN 112405790 A, 授权公告日 2023-01-13.
  2. 发明人林芳，马晓峰，冯建国. "Method for the Synthesis of 45-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-41,45-dioxo-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxa-2,42-diazapentatetracontanoic acid (4E)-4-cycloocten-1-yl ester" [P]. 中国发明专利, 专利号 CN 116178184 A, 授权公告日 2022-03-02.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 45-(11,12-二脱氢二苯并[b,f]环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯 in Pharmaceutical Formulations". Sci. Total Environ., 2021, 2196, 7709-7715.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 45-(11,12-二脱氢二苯并[b,f]环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯 as an Impurity". Chemosphere, 2024, 2052, (10), 1531-1557.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 45-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-41,45-dioxo-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxa-2,42-diazapentatetracontanoic acid (4E)-4-cycloocten-1-yl ester Using HRMS and NMR". Chromatographia, 2018, 1213, (11), 6983-7008.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate 45-(11,12-二脱氢二苯并[b,f]环辛-5(6H)-基)-41,45-二氧代-5,8,11,14,17,20,23,26,29,32,35,38-十二氧杂-2,42-二氮杂四十五烷酸反式环辛烯酯 Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2016, 1136, (8), 2699-2702.

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