2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride CAS 2059949-19-6

2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride

纯度 97%+现货药物标准品
CAS 号2059949-19-6
分子式C12H11F3N4O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride 2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride CAS 2059949-19-6 结构式 Chemical Structure

产品介绍 Description

2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride（2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 2059949-19-6。分子式 C12H11F3N4O 2*HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

2-{5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 2-{5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride（2-{5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride），CAS注册编号 2059949-19-6，化学分子式为 C12H11F3N4O 2HCl，分子量 320.70 g/mol。 2-{5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride（C12H11F3N4

应用场景：在化学分析实验室中，2-{5- 3-(trifluoromethyl)pyrrolidin-3-yl -1,2,4-oxadiazol-3-yl}pyridine dihydrochloride（CAS 2059949-19-6）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以2-{5- 3-(trifluoromethyl)pyrrolidin-3-yl -1,2,4-oxadiazol-3-yl}pyridine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀

理化性质 Physical & Chemical Properties

中文名称2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride
分子式C12H11F3N4O 2*HCl
分子量320.70 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量F/Cl取代
含氮原子数4

相关专利 Related Patents

  1. Patel M V, Hughes D C, Brown S R. "一种2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride的合成方法" [P]. US Patent, US 9980564 B2, 2023-11-03.
  2. 发明人沈红梅，高志强，刘建华. "Method for the Synthesis of 2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride" [P]. 中国发明专利, 专利号 CN 110463906 B, 授权公告日 2019-03-01.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride in Pharmaceutical Formulations". Anal. Chem., 2012, 1067, 5111-5133.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride as an Impurity". Chemosphere, 2015, 367, (3), 253-261.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 2-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride Using HRMS and NMR". Sci. Total Environ., 2012, 615, (12), 7851-7875.

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