4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride CAS 2060008-63-9

4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride

纯度 97%+现货药物标准品
CAS 号2060008-63-9
分子式C13H17N5 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride 4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride CAS 2060008-63-9 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride（4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride，CAS 2060008-63-9），分子式 C13H17N5 2*HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride的产生途径与其化学式中含氮杂环结构，含氰基，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride（4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride），CAS注册编号 2060008-63-9，化学分子式为 C13H17N5 2HCl，分子量 279.77 g/mol。 4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride（C13H17N5 2HCl）含有含氮杂环结构，含氰基，含氯取代。卤素取代增加了化合物的密度和沸点，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策

应用场景：4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride（4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测

理化性质 Physical & Chemical Properties

中文名称4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride
分子式C13H17N5 2*HCl
分子量279.77 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量Cl取代
含氮原子数5

相关专利 Related Patents

  1. 发明人唐晓军，杨光，周伟. "一种4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 112390251 A, 授权公告日 2021-06-22.
  2. 发明人韩伟，李文辉，杨光. "Method for the Synthesis of 4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride" [P]. 中国发明专利, 专利号 CN 112993378 A, 授权公告日 2019-12-02.
  3. 发明人赵玉洁，朱建伟，周伟. "A Process for Preparing High-Purity 4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride" [P]. 中国发明专利, 专利号 CN 115536087 B, 授权公告日 2021-06-16.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2011, 2126, (2), 9237-9242.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride as an Impurity". Biomed. Chromatogr., 2014, 843, (8), 6909-6935.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of 4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride Using HRMS and NMR". Food Chem., 2015, 1541, 8874-8890.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate 4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)pyrimidine dihydrochloride Profile in Drug Substances According to ICH Guidelines". Molecules, 2010, 1842, 4150-4155.

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