tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate CAS 206989-63-1

tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate

纯度 97%+现货药物标准品
CAS 号206989-63-1
分子式C18H27N3O2
分子量317.43 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate CAS 206989-63-1 结构式 Chemical Structure

产品介绍 Description

tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate（tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate）是药物分析与质量控制领域常用的药物标准品，CAS 号 206989-63-1。分子式 C18H27N3O2，分子量 317.43。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate的分子量为317.43 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate（tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate），CAS注册编号 206989-63-1，化学分子式为 C18H27N3O2，分子量 317.43 g/mol。 tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate（分子式 C18H27N3O2）的化学结构中包含甾体骨架，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质

应用场景：针对化学分析用途，tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate（tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate）是具有明确定量溯源的认证级对照品。 推荐以tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议

理化性质 Physical & Chemical Properties

中文名称tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate
分子式C18H27N3O2
分子量317.43 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2016年
含氮原子数3

相关专利 Related Patents

  1. 发明人李文辉，黄志刚，韩伟. "一种tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 114770722 B, 授权公告日 2017-07-23.
  2. 发明人杨光，黄志刚，李文辉. "Method for the Synthesis of tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate" [P]. 中国发明专利, 专利号 CN 115276332 B, 授权公告日 2023-05-09.
  3. Davis P L, Mueller T, Klinger H. "A Process for Preparing High-Purity tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate" [P]. US Patent, US 11451492 B2, 2023-10-07.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate in Pharmaceutical Formulations". Anal. Chem., 2017, 1761, 2287-2306.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate as an Impurity". J. Nat. Prod., 2024, 1239, (9), 5321-5331.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate Using HRMS and NMR". J. Chromatogr. A, 2020, 2180, 3701-3724.

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