Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt CAS 2071741-36-9

纯度 97%+现货药物标准品
CAS 号2071741-36-9
分子式C20H37NP2 C10H18CoO4
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt CAS 2071741-36-9 结构式 Chemical Structure

产品介绍 Description

CAS 2071741-36-9 对应的Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt（Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt）为 CATO 佳途药物标准品产品线成员。分子式 C20H37NP2 C10H18CoO4。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括Bisdiisopropylphosphinomethyl-4-methyl-pyridine bis(pivaloyloxy)cobalt在内的目标物的控制。 CAS编号 2071741-36-9 对应的化合物Bisdiisopropylphosphinomethyl-4-methyl-pyridine bis(pivaloyloxy)cobalt（英文标识 Bisdiisopropylphosphinomethyl-4-methyl-pyridine bis(pivaloyloxy)cobalt），化学式 C20H37NP2 C10H18CoO4，相对分子质量 614.65。 从化学结构特征来看，Bisdiisopropylphosphinomethyl-4-methyl-pyridine bis(pivaloyloxy)cobalt的分子骨架中包含甾体骨架，酰胺类，含磷酸酯基，含羟基，含醚键。该化合物的不饱和度为4.0，表明结构中存在约4个环或双键等价单元。分子量为614.65 g/m

应用场景：在化学分析实验室中，Bis diisopropylphosphino methyl -4-methyl-pyridine bis(pivaloyloxy)cobalt（CAS 2071741-36-9）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以Bis diisopropylphosphino methyl -4-methyl-pyridine bis(pivaloyloxy)cobalt配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器

理化性质 Physical & Chemical Properties

中文名称Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt
分子式C20H37NP2 C10H18CoO4
分子量614.65 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
含氮原子数1

相关专利 Related Patents

  1. 发明人杨光，朱建伟，王建平. "一种Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt的合成方法" [P]. 中国发明专利, 专利号 CN 117809130 B, 授权公告日 2019-03-12.
  2. Park J H, Klinger H, Kumar R. "Method for the Synthesis of Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt" [P]. US Patent, US 10540030 B2, 2016-04-25.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt in Pharmaceutical Formulations". J. Sep. Sci., 2016, 883, (9), 1581-1603.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt as an Impurity". J. Agric. Food Chem., 2015, 1217, (6), 2437-2466.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt Using HRMS and NMR". Food Chem., 2012, 945, 2202-2229.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate Bis[[diisopropylphosphino]methyl]-4-methyl-pyridine bis(pivaloyloxy)cobalt Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2012, 717, 9958-9981.

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