Fmoc-β-Glu(OtBu)-OH CAS 209252-17-5

(3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxidanylidene-pentanoic acid (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid (3R)-3-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-keto-valeric acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-pentanoic acid 209252-17-5 Fmoc-beta-homoaspartic acid(OtBu)

纯度 97%+现货药物标准品
CAS 号209252-17-5
分子式C24H39NO6
分子量437.57 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Fmoc-β-Glu(OtBu)-OH (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxidanylidene-pentanoic acid (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid (3R)-3-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-keto-valeric acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-pentanoic acid 209252-17-5 Fmoc-beta-homoaspartic acid(OtBu) CAS 209252-17-5 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品Fmoc-β-Glu(OtBu)-OH（(3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxidanylidene-pentanoic acid (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid (3R)-3-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-keto-valeric acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-pentanoic acid 209252-17-5 Fmoc-beta-homoaspartic acid(OtBu)，CAS 209252-17-5），分子式 C24H39NO6，分子量 437.57。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

Fmoc-β-Glu(OtBu)-OH（(3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(2-methylpropan-2-yl)oxy-5-oxidanylidene-pentanoic acid (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(2-methylpropan-2-yl)oxy-5-oxopentanoic acid (3R)-3-9H-fluoren-9-ylmethoxy(oxo)methylamino-5-(2-methylpropan-2-yl)oxy-5-oxopentanoic acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-keto-valeric acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-pentanoic acid 209252-17-5 Fmoc-beta-h

应用场景：在化学分析实验室中，Fmoc-β-Glu(OtBu)-OH（CAS 209252-17-5）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以Fmoc-β-Glu(OtBu)-OH配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于室温保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境

理化性质 Physical & Chemical Properties

中文名称Fmoc-β-Glu(OtBu)-OH
分子式C24H39NO6
分子量437.57 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2016年
含氮原子数1

相关专利 Related Patents

  1. 发明人孙丽萍，郑宇鹏，高志强. "一种Fmoc-β-Glu(OtBu)-OH的合成方法" [P]. 中国发明专利, 专利号 CN 115624822 B, 授权公告日 2015-09-20.
  2. 发明人张德明，高志强，徐明华. "Method for the Synthesis of (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxidanylidene-pentanoic acid (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid (3R)-3-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-keto-valeric acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-pentanoic acid 209252-17-5 Fmoc-beta-homoaspartic acid(OtBu)" [P]. 中国发明专利, 专利号 CN 112354084 A, 授权公告日 2023-10-04.
  3. Sørensen M, Nowak P, Kowalski A. "A Process for Preparing High-Purity (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxidanylidene-pentanoic acid (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid (3R)-3-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-keto-valeric acid (3R)-5-tert-butoxy-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-pentanoic acid 209252-17-5 Fmoc-beta-homoaspartic acid(OtBu)" [P]. European Patent, EP 3471056 A1, 2017-06-27.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of Fmoc-β-Glu(OtBu)-OH in Pharmaceutical Formulations". Anal. Methods, 2013, 2136, 4611-4641.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of Fmoc-β-Glu(OtBu)-OH as an Impurity". J. Sep. Sci., 2023, 1438, (5), 6390-6394.

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