6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one CAS 210360-85-3
6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one
| CAS 号 | 210360-85-3 |
| 分子式 | C17H11NO3 |
| 分子量 | 277.27 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 210360-85-3 对应的6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one（6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one）为 CATO 佳途药物标准品产品线成员。分子式 C17H11NO3，分子量 277.27。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
作为认证标准物质（CRM），6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C17H11NO3 的6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one（6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one），其CAS登记号是 210360-85-3，分子量为 277.27 g/mol。 受分子结构中甾体骨架，酰胺类，含羟基，含醚键的影响，6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one表现为淡黄色至黄色结晶性粉末。其固体形态的物理化学属性—
应用场景：从实际应用出发，6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one（CAS 210360-85-3）在化学分析中作为关键的基准对照物质。 推荐以6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用
理化性质 Physical & Chemical Properties
| 中文名称 | 6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one |
| 分子式 | C17H11NO3 |
| 分子量 | 277.27 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 13.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 2017年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人唐晓军，韩伟，马晓峰. "一种6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one的合成方法" [P]. 中国发明专利, 专利号 CN 112143024 A, 授权公告日 2017-03-14.
- Patel M V, Fischer A B, Yamamoto T. "Method for the Synthesis of 6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one" [P]. US Patent, US 10450725 B2, 2017-03-22.
参考文献 Literature
- O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2016, 2208, (12), 6897-6927.
- Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one as an Impurity". Chemosphere, 2010, 107, (12), 5210-5214.
- Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one Using HRMS and NMR". J. Sep. Sci., 2017, 2044, 3664-3691.
- Fischer P, Wagner E. "Forced Degradation Studies to Evaluate 6-hydroxy-2-(1H-indol-3-ylmethylidene)-2,3-dihydro-1-benzofuran-3-one Profile in Drug Substances According to ICH Guidelines". Talanta, 2025, 1158, (3), 5380-5386.
Related hydroxy Standards 同系列产品
- 4-Hydroxy-5-((4-methoxybenzyl)oxy)-1,4-dihydropyridine-2-carboxylic acid (CAS 1632286-08-8)
- 2-(((7-Hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methyl)(methyl)amino)acetic acid (CAS 54696-41-2)
- Ethyl 4-hydroxy-5,7-dimethoxyquinoline-3-carboxylate (CAS 26893-03-8)
- Ethyl 4-hydroxy-5-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate (CAS 248282-13-5)
- Methyl 2-(4-hydroxy-1-((5-methylfuran-2-yl)methyl)-2-oxo-1,2-dihydropyridin-3-yl)acetate (CAS 477864-38-3)
- 3-(4-羟基-3-甲氧基苯基)-1-甲基四氢吡咯并[3,4-c]吡唑-4,6(1H,5H)-二酮 (CAS 1005271-00-0)
- N'-hydroxy-6-(3-(3-methylisoxazol-5-yl)propoxy)pyridazine-3-carboximidamide (CAS 1105194-43-1)
- 6-Hydroxy-2-phenyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one (CAS 1315307-77-7)
推荐产品 Recommended Standards
- 2,2-二甲基-5-[(3-甲氧基苯基氨基)亚甲基]-1,3-二氧六环-4,6-二酮 (CAS 213699-52-6)
- 7-Formylquinolin-8-ylbenzoate (CAS 936497-79-9)
- 5',5'-Dimethyl-3-oxo-3,4,4',5'-tetrahydro-2'H-spiro[benzo[b][1,4]oxazine-2,3'-furan]-6-carboxylic acid (CAS 2658493-90-2)
- 5-溴-6-氯-4-嘧啶酮 (CAS 89089-19-0)
- (S)-2-((3-Methoxyphenoxy)methyl)morpholine hydrochloride (CAS 55253-30-0)
- 2-[(3-Bromophenyl)formamido]ethyl N-(4-chlorophenyl)carbamate (CAS 478066-82-9)
- 5-Amino-N-acetyltryptamine (CAS 393835-65-9)
- [3-(4-Aminophenoxy)phenyl]boronic acid (CAS 2096333-48-9)
- 双DSPE PEG2000 (CAS 2260795-82-0)
- Rac1抑制剂F56，对照肽 (CAS 1315378-77-8)
为什么选择 CATO 佳途？
- ISO 17034 / CNAS / ANAB 三重认证标准物质生产商
- 130,000+ 品种现货库存，支持 COA 定制
- 专业技术支持：+86 13829788188 / jacky.chen@cato-chem.com
- 全球 10,000+ 客户信赖之选