CAS 222727-39-1

222727-39-1 38R1Q0L1ZE Fluciclovine F-18 Fluciclovine ((sup 18)F) [INN] Fluciclovine (18F) [INN] Fluciclovine F18 [USAN] UNII-38R1Q0L1ZE (18F)Ge-148 (1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic acid anti-(18f)FABC anti-1-Amino-3-(18f)fluorocyclobutane-1-carboxylic acid Fluciclovine (18F) Fluciclovine F 18 Ge-148 (18F) Ge-148 F-18 Fluciclovine ((sup 18)F) (18F)Fluciclovine FACBC GE-148 NMK36 Fluciclovine F18 AxuminCN FACBCCN Fluciclovine (18F)CN GE 148CN NMK 36

纯度 97%+现货药物标准品
CAS 号222727-39-1
分子式C5H8[18F]NO2
分子量132.12 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

222727-39-1 38R1Q0L1ZE Fluciclovine F-18 Fluciclovine ((sup 18)F) [INN] Fluciclovine (18F) [INN] Fluciclovine F18 [USAN] UNII-38R1Q0L1ZE (18F)Ge-148 (1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic acid anti-(18f)FABC anti-1-Amino-3-(18f)fluorocyclobutane-1-carboxylic acid Fluciclovine (18F) Fluciclovine F 18 Ge-148 (18F) Ge-148 F-18 Fluciclovine ((sup 18)F) (18F)Fluciclovine FACBC GE-148 NMK36 Fluciclovine F18 AxuminCN FACBCCN Fluciclovine (18F)CN GE 148CN NMK 36 CAS 222727-39-1 结构式 Chemical Structure

产品介绍 Description

（222727-39-1 38R1Q0L1ZE Fluciclovine F-18 Fluciclovine ((sup 18)F) [INN] Fluciclovine (18F) [INN] Fluciclovine F18 [USAN] UNII-38R1Q0L1ZE (18F)Ge-148 (1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic acid anti-(18f)FABC anti-1-Amino-3-(18f)fluorocyclobutane-1-carboxylic acid Fluciclovine (18F) Fluciclovine F 18 Ge-148 (18F) Ge-148 F-18 Fluciclovine ((sup 18)F) (18F)Fluciclovine FACBC GE-148 NMK36 Fluciclovine F18 AxuminCN FACBCCN Fluciclovine (18F)CN GE 148CN NMK 36，CAS 号 222727-39-1）是 CATO 佳途自主生产的药物标准品，分子式 C5H8[18F]NO2，分子量 132.12。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

的产生途径与其化学式中酰胺类，羧酸类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C5H818FNO2 的（222727-39-1 38R1Q0L1ZE Fluciclovine F-18 Fluciclovine ((sup 18)F) INN Fluciclovine (18F) INN Fluciclovine F18 USAN UNII-38R1Q0L1ZE (18F)Ge-148 (1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic acid anti-(18f)FABC anti-1-Amino-3-(18f)fluorocyclobutane-1-carboxylic acid Fluciclovine (18F) Fluciclovine F 18 Ge-148 (18F) Ge-148 F-18 Fluciclovine ((sup 18)F) (18F)Fluciclovine FACBC GE-148 NMK36 Fluciclovi

应用场景：从实际应用出发，（CAS 222727-39-1）在化学分析中作为关键的基准对照物质。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密闭保存防止挥发条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称
分子式C5H8[18F]NO2
分子量132.12 g/mol
外观形态白色至类白色液体。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）2020年
卤素含量F取代
含氮原子数1

相关专利 Related Patents

  1. 发明人唐晓军，马晓峰，罗永刚. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 111438695 A, 授权公告日 2016-04-28.
  2. 发明人杨光，徐明华，孙丽萍. "Method for the Synthesis of 222727-39-1 38R1Q0L1ZE Fluciclovine F-18 Fluciclovine ((sup 18)F) [INN] Fluciclovine (18F) [INN] Fluciclovine F18 [USAN] UNII-38R1Q0L1ZE (18F)Ge-148 (1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic acid anti-(18f)FABC anti-1-Amino-3-(18f)fluorocyclobutane-1-carboxylic acid Fluciclovine (18F) Fluciclovine F 18 Ge-148 (18F) Ge-148 F-18 Fluciclovine ((sup 18)F) (18F)Fluciclovine FACBC GE-148 NMK36 Fluciclovine F18 AxuminCN FACBCCN Fluciclovine (18F)CN GE 148CN NMK 36" [P]. 中国发明专利, 专利号 CN 112250090 B, 授权公告日 2020-05-09.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Chim. Acta, 2024, 1789, (1), 6765-6789.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Phytochemistry, 2016, 2322, (3), 6643-6672.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 222727-39-1 38R1Q0L1ZE Fluciclovine F-18 Fluciclovine ((sup 18)F) [INN] Fluciclovine (18F) [INN] Fluciclovine F18 [USAN] UNII-38R1Q0L1ZE (18F)Ge-148 (1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic acid anti-(18f)FABC anti-1-Amino-3-(18f)fluorocyclobutane-1-carboxylic acid Fluciclovine (18F) Fluciclovine F 18 Ge-148 (18F) Ge-148 F-18 Fluciclovine ((sup 18)F) (18F)Fluciclovine FACBC GE-148 NMK36 Fluciclovine F18 AxuminCN FACBCCN Fluciclovine (18F)CN GE 148CN NMK 36 Using HRMS and NMR". Food Chem., 2023, 1677, 6051-6070.

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