(1R,1'R,1''R)-(((1S,1'S,1''S)-Bortezomib三聚体 CAS 2304631-76-1

N,N',N''-((1R,1'R,1''R)-(((1S,1'S,1''S)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(2-oxo-1-phenylethane-2,1-diyl))tris(pyrazine-2-carboxamide)

纯度 97%+现货药物标准品
CAS 号2304631-76-1
分子式C54H63B3N12O9
分子量1056.59 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(1R,1'R,1''R)-(((1S,1'S,1''S)-Bortezomib三聚体 N,N',N''-((1R,1'R,1''R)-(((1S,1'S,1''S)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(2-oxo-1-phenylethane-2,1-diyl))tris(pyrazine-2-carboxamide) CAS 2304631-76-1 结构式 Chemical Structure

产品介绍 Description

CAS 2304631-76-1 对应的(1R,1'R,1''R)-(((1S,1'S,1''S)-Bortezomib三聚体（N,N',N''-((1R,1'R,1''R)-(((1S,1'S,1''S)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(2-oxo-1-phenylethane-2,1-diyl))tris(pyrazine-2-carboxamide)）为 CATO 佳途药物标准品产品线成员。分子式 C54H63B3N12O9，分子量 1056.59。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在质量保证方面，(1R,1'R,1''R)-(((1S,1'S,1''S)-Bortezomib三聚体的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C54H63B3N12O9 的(1R,1'R,1''R)-(((1S,1'S,1''S)-Bortezomib三聚体（N,N',N''-((1R,1'R,1''R)-(((1S,1'S,1''S)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(2-oxo-1-phenylethane-2,1-diyl))tris(pyrazine-2-carboxamide)），其CAS登记号是 2304631-76-1，分子量为 1056.59 g/mol。 依据分子式为 C54H

应用场景：针对化学分析用途，(1R,1'R,1''R)-(((1S,1'S,1''S)-Bortezomib三聚体（N,N',N''-((1R,1'R,1''R)-(((1S,1'S,1''S)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(2-oxo-1-phenylethane-2,1-diyl))tris(pyrazine-2-carboxamide)）是具有明确定量溯源的认证级对照品。 推荐以(1R,1'R,1''R)-(((1S,1'S,1''S)-B

理化性质 Physical & Chemical Properties

中文名称(1R,1'R,1''R)-(((1S,1'S,1''S)-Bortezomib三聚体
分子式C54H63B3N12O9
分子量1056.59 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）29.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1999年
含氮原子数12

相关专利 Related Patents

  1. 发明人孙丽萍，李文辉，马晓峰. "一种(1R,1'R,1''R)-(((1S,1'S,1''S)-Bortezomib三聚体的合成方法" [P]. 中国发明专利, 专利号 CN 110710885 A, 授权公告日 2018-04-15.
  2. 发明人高志强，唐晓军，郑宇鹏. "Method for the Synthesis of N,N',N''-((1R,1'R,1''R)-(((1S,1'S,1''S)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(2-oxo-1-phenylethane-2,1-diyl))tris(pyrazine-2-carboxamide)" [P]. 中国发明专利, 专利号 CN 108347113 B, 授权公告日 2019-01-19.
  3. 发明人徐明华，周伟，沈红梅. "A Process for Preparing High-Purity N,N',N''-((1R,1'R,1''R)-(((1S,1'S,1''S)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(2-oxo-1-phenylethane-2,1-diyl))tris(pyrazine-2-carboxamide)" [P]. 中国发明专利, 专利号 CN 117067515 B, 授权公告日 2023-10-16.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of (1R,1'R,1''R)-(((1S,1'S,1''S)-Bortezomib三聚体 in Pharmaceutical Formulations". Food Chem., 2016, 83, (11), 6415-6437.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of (1R,1'R,1''R)-(((1S,1'S,1''S)-Bortezomib三聚体 as an Impurity". Rapid Commun. Mass Spectrom., 2025, 1582, 7825-7836.

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