氯化尼罗兰 CAS 2381-85-3

2381-85-3 Nile Blue C.I. Basic Blue 12 (8CI) 5-Amino-9-(diethylamino)benzo(a)phenoxazin-7-ium chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride (1:1) C.I. 51180 C.I. Basic Blue 12 Basic Blue 12 5H-Benzo(a)phenazoxazine, 9-diethylamino-5-imino-, hydrochloride Benzo(a)phenazoxonium, 5-amino-9-(diethylamino)-, chloride Cresol Fast Violet Cresyl Fast Violet EINECS 219-181-4 Nile Blue A Nile Blue AX Nile Blue Base Nile Blue chloride Nile Blue hydrochloride NSC 146184

纯度 97%+现货药物标准品
CAS 号2381-85-3
分子式C20H30N3O Cl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

氯化尼罗兰 2381-85-3 Nile Blue C.I. Basic Blue 12 (8CI) 5-Amino-9-(diethylamino)benzo(a)phenoxazin-7-ium chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride (1:1) C.I. 51180 C.I. Basic Blue 12 Basic Blue 12 5H-Benzo(a)phenazoxazine, 9-diethylamino-5-imino-, hydrochloride Benzo(a)phenazoxonium, 5-amino-9-(diethylamino)-, chloride Cresol Fast Violet Cresyl Fast Violet EINECS 219-181-4 Nile Blue A Nile Blue AX Nile Blue Base Nile Blue chloride Nile Blue hydrochloride NSC 146184 CAS 2381-85-3 结构式 Chemical Structure

产品介绍 Description

氯化尼罗兰（2381-85-3 Nile Blue C.I. Basic Blue 12 (8CI) 5-Amino-9-(diethylamino)benzo(a)phenoxazin-7-ium chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride (1:1) C.I. 51180 C.I. Basic Blue 12 Basic Blue 12 5H-Benzo(a)phenazoxazine, 9-diethylamino-5-imino-, hydrochloride Benzo(a)phenazoxonium, 5-amino-9-(diethylamino)-, chloride Cresol Fast Violet Cresyl Fast Violet EINECS 219-181-4 Nile Blue A Nile Blue AX Nile Blue Base Nile Blue chloride Nile Blue hydrochloride NSC 146184）是药物分析与质量控制领域常用的药物标准品，CAS 号 2381-85-3。分子式 C20H30N3O Cl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

化学式为 C20H30N3O Cl 的氯化尼罗兰（2381-85-3 Nile Blue C.I. Basic Blue 12 (8CI) 5-Amino-9-(diethylamino)benzo(a)phenoxazin-7-ium chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride (1:1) C.I. 51180 C.I. Basic Blue 12 Basic Blue 12 5H-Benzo(a)phenazoxazine, 9-diethylamino-5-imino-, hydrochloride Benzo(a)phenazoxonium, 5-amino-9-(diethylamino)-, chloride Cresol Fast Violet Cresyl Fast Violet EINECS 219-181-4 Nile Blue A Nile Bl

应用场景：从实际应用出发，氯化尼罗兰（CAS 2381-85-3）在化学分析中作为关键的基准对照物质。 推荐以氯化尼罗兰配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称氯化尼罗兰
分子式C20H30N3O Cl
分子量363.93 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. Thompson G K, Anderson J P, Fischer A B. "一种氯化尼罗兰的合成方法" [P]. US Patent, US 9308881 B2, 2025-10-21.
  2. Hughes D C, Lee S K, Thompson G K. "Method for the Synthesis of 2381-85-3 Nile Blue C.I. Basic Blue 12 (8CI) 5-Amino-9-(diethylamino)benzo(a)phenoxazin-7-ium chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride (1:1) C.I. 51180 C.I. Basic Blue 12 Basic Blue 12 5H-Benzo(a)phenazoxazine, 9-diethylamino-5-imino-, hydrochloride Benzo(a)phenazoxonium, 5-amino-9-(diethylamino)-, chloride Cresol Fast Violet Cresyl Fast Violet EINECS 219-181-4 Nile Blue A Nile Blue AX Nile Blue Base Nile Blue chloride Nile Blue hydrochloride NSC 146184" [P]. US Patent, US 10890856 B2, 2023-04-21.
  3. 发明人冯建国，郭海燕，沈红梅. "A Process for Preparing High-Purity 2381-85-3 Nile Blue C.I. Basic Blue 12 (8CI) 5-Amino-9-(diethylamino)benzo(a)phenoxazin-7-ium chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride (1:1) C.I. 51180 C.I. Basic Blue 12 Basic Blue 12 5H-Benzo(a)phenazoxazine, 9-diethylamino-5-imino-, hydrochloride Benzo(a)phenazoxonium, 5-amino-9-(diethylamino)-, chloride Cresol Fast Violet Cresyl Fast Violet EINECS 219-181-4 Nile Blue A Nile Blue AX Nile Blue Base Nile Blue chloride Nile Blue hydrochloride NSC 146184" [P]. 中国发明专利, 专利号 CN 109237455 A, 授权公告日 2025-12-27.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 氯化尼罗兰 in Pharmaceutical Formulations". Anal. Chem., 2016, 1207, (10), 7642-7665.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 氯化尼罗兰 as an Impurity". Anal. Chim. Acta, 2025, 597, 3826-3849.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 2381-85-3 Nile Blue C.I. Basic Blue 12 (8CI) 5-Amino-9-(diethylamino)benzo(a)phenoxazin-7-ium chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride Benzo(a)phenoxazin-7-ium, 5-amino-9-(diethylamino)-, chloride (1:1) C.I. 51180 C.I. Basic Blue 12 Basic Blue 12 5H-Benzo(a)phenazoxazine, 9-diethylamino-5-imino-, hydrochloride Benzo(a)phenazoxonium, 5-amino-9-(diethylamino)-, chloride Cresol Fast Violet Cresyl Fast Violet EINECS 219-181-4 Nile Blue A Nile Blue AX Nile Blue Base Nile Blue chloride Nile Blue hydrochloride NSC 146184 Using HRMS and NMR". Phytochemistry, 2020, 1285, (12), 7644-7669.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 氯化尼罗兰 Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2019, 742, (8), 3351-3365.

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