CAS 2414594-37-7

(2S)-2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[2-[[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methylsulfanyl]ethylsulfanylmethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-N'-methyl-N'-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanediamide

纯度 97%+现货药物标准品
CAS 号2414594-37-7
分子式C53H68FN9O17S2
分子量1186.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2S)-2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[2-[[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methylsulfanyl]ethylsulfanylmethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-N'-methyl-N'-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanediamide CAS 2414594-37-7 结构式 Chemical Structure

产品介绍 Description

（(2S)-2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[2-[[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methylsulfanyl]ethylsulfanylmethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-N'-methyl-N'-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanediamide，CAS 号 2414594-37-7）是 CATO 佳途自主生产的药物标准品，分子式 C53H68FN9O17S2，分子量 1186.29。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 （(2S)-2-3-(2,5-dioxopyrrol-1-yl)propanoylamino-N-(1S)-2-(1S)-2-(1S)-2-2-(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo11.8.0.0²¹¹.0⁴⁹.0¹⁵²ºhenicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-ylmethylsulfanylethylsulfanylmethylamino-1-methyl-2-oxo-ethylamino-1-methyl-2-oxo-ethylamino-1-meth

应用场景：（(2S)-2- 3-(2,5-dioxopyrrol-1-yl)propanoylamino -N- (1S)-2- (1S)-2- (1S)-2- 2- (19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo 11.8.0.0²¹¹.0⁴⁹.0¹⁵²º henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl methylsulfanyl ethylsulfanylmethylamino -1-methyl-2-oxo-ethyl ami

理化性质 Physical & Chemical Properties

中文名称
分子式C53H68FN9O17S2
分子量1186.29 g/mol
外观形态淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）24.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2000年
卤素含量F取代
含氮原子数9
含硫原子数2

相关专利 Related Patents

  1. 发明人李文辉，唐晓军，钱学锋. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 111686159 A, 授权公告日 2022-05-13.
  2. Yamamoto T, Lee S K, Anderson J P. "Method for the Synthesis of (2S)-2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[2-[[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methylsulfanyl]ethylsulfanylmethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-N'-methyl-N'-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanediamide" [P]. US Patent, US 11214415 B2, 2018-06-18.
  3. 发明人张德明，胡光，赵玉洁. "A Process for Preparing High-Purity (2S)-2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[2-[[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methylsulfanyl]ethylsulfanylmethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-N'-methyl-N'-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanediamide" [P]. 中国发明专利, 专利号 CN 112128618 A, 授权公告日 2016-09-17.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Methods, 2014, 1310, (3), 6126-6147.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chim. Acta, 2016, 1875, (6), 242-271.

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