CAS 2414594-32-2

6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[4-[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]butoxymethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]hexanamide

纯度 97%+现货药物标准品
CAS 号2414594-32-2
分子式C45H54FN7O11
分子量887.95 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[4-[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]butoxymethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]hexanamide CAS 2414594-32-2 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品（6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[4-[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]butoxymethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]hexanamide，CAS 2414594-32-2），分子式 C45H54FN7O11，分子量 887.95。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 （6-(2,5-dioxopyrrol-1-yl)-N-(1S)-2-(1S)-2-(1S)-2-4-(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo11.8.0.0²¹¹.0⁴⁹.0¹⁵²ºhenicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-ylbutoxymethylamino-1-methyl-2-oxo-ethylamino-1-methyl-2-oxo-ethylamino-1-methyl-2-oxo-ethylhexanamide），CAS注册编号 2414594-32-2，化学分子式为 C45H54FN7O11，分子量 887.95 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代的影响，表现为淡黄色至黄色无定形粉末。（具

应用场景：（6-(2,5-dioxopyrrol-1-yl)-N- (1S)-2- (1S)-2- (1S)-2- 4- (19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo 11.8.0.0²¹¹.0⁴⁹.0¹⁵²º henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl butoxymethylamino -1-methyl-2-oxo-ethyl amino -1-methyl-2-oxo-ethyl amino -1-methyl-2-oxo

理化性质 Physical & Chemical Properties

中文名称
分子式C45H54FN7O11
分子量887.95 g/mol
外观形态淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）22.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2000年
卤素含量F取代
含氮原子数7

相关专利 Related Patents

  1. Chen K W, Roberts E F, Davis P L. "一种的合成方法" [P]. US Patent, US 10859424 B2, 2023-12-02.
  2. Johnson M A, Park J H, Anderson J P. "Method for the Synthesis of 6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[4-[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]butoxymethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]hexanamide" [P]. US Patent, US 10244829 B2, 2019-10-05.
  3. 发明人沈红梅，徐明华，郭海燕. "A Process for Preparing High-Purity 6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[4-[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]butoxymethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]hexanamide" [P]. 中国发明专利, 专利号 CN 115493830 A, 授权公告日 2017-08-08.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Phytochemistry, 2015, 1146, 3912-3925.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Agric. Food Chem., 2023, 2178, (3), 2803-2821.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-2-[[(1S)-2-[[(1S)-2-[4-[(19S)-19-ethyl-6-fluoro-19-hydroxy-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²¹¹.0⁴⁹.0¹⁵²º]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]butoxymethylamino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]hexanamide Using HRMS and NMR". Environ. Sci. Technol., 2017, 1033, (3), 2005-2023.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2012, 1987, (8), 2596-2617.

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