CAS 2495742-34-0

1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-N-[(1S)-1-{[(1S)-1-{[(10S)-10-ethyl-10-hydroxy-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-19-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide

纯度 97%+现货药物标准品
CAS 号2495742-34-0
分子式C57H77N7O18
分子量1148.26 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-N-[(1S)-1-{[(1S)-1-{[(10S)-10-ethyl-10-hydroxy-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-19-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide CAS 2495742-34-0 结构式 Chemical Structure

产品介绍 Description

（1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-N-[(1S)-1-{[(1S)-1-{[(10S)-10-ethyl-10-hydroxy-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-19-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide，CAS 号 2495742-34-0）是 CATO 佳途自主生产的药物标准品，分子式 C57H77N7O18，分子量 1148.26。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 （1-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido-N-(1S)-1-{(1S)-1-{(10S)-10-ethyl-10-hydroxy-5,9-dioxo-8-oxa-4,15-diazahexacyclo14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-19-ylcarbamoyl}ethylcarbamoyl}-2-methylpropyl-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide），CAS注册编号 2495742-34-0，化学分子式为 C57H77N7O18，分子量 1148.26 g/mol。 （C57H77N7O18）含有含氮杂环结构，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基

应用场景：（1- 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido -N- (1S)-1-{ (1S)-1-{ (10S)-10-ethyl-10-hydroxy-5,9-dioxo-8-oxa-4,15-diazahexacyclo 14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴ tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-19-yl carbamoyl}ethyl carbamoyl}-2-methylpropyl -3,6,9,12,15,18,21,24-octaoxaheptac

理化性质 Physical & Chemical Properties

中文名称
分子式C57H77N7O18
分子量1148.26 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）23.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2000年
含氮原子数7

相关专利 Related Patents

  1. Martínez F, Mueller T C, Johansson L. "一种的合成方法" [P]. European Patent, EP 3663250 A1, 2017-06-10.
  2. Nielsen H, Björnsson E, Nowak P. "Method for the Synthesis of 1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-N-[(1S)-1-{[(1S)-1-{[(10S)-10-ethyl-10-hydroxy-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-19-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide" [P]. European Patent, EP 3807201 A1, 2025-10-06.
  3. Fischer A B, Johnson M A, Davis P L. "A Process for Preparing High-Purity 1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-N-[(1S)-1-{[(1S)-1-{[(10S)-10-ethyl-10-hydroxy-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-19-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide" [P]. US Patent, US 11734478 B2, 2025-09-18.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Chromatogr. A, 2016, 571, 2779-2795.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Sep. Sci., 2011, 145, (5), 2159-2183.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-N-[(1S)-1-{[(1S)-1-{[(10S)-10-ethyl-10-hydroxy-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-19-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide Using HRMS and NMR". Molecules, 2019, 1552, 1032-1055.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2019, 1305, (5), 6846-6851.

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