(1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO[3,4-A]PYRAZINE-5,8-DIONE CAS 249611-05-0
(1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO[3,4-A]PYRAZINE-5,8-DIONE
| CAS 号 | 249611-05-0 |
| 分子式 | C13H14N2O3 |
| 分子量 | 246.26 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
(1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO[3,4-A]PYRAZINE-5,8-DIONE（(1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO[3,4-A]PYRAZINE-5,8-DIONE，CAS 号 249611-05-0）是 CATO 佳途自主生产的药物标准品，分子式 C13H14N2O3，分子量 246.26。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO3,4-APYRAZINE-5,8-DIONE在内的目标物的控制。 CAS编号 249611-05-0 对应的化合物(1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO3,4-APYRAZINE-5,8-DIONE（英文标识 (1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO3,4-APYRAZINE-5,8-DIONE），化学式 C13H14N2O3，相对分子质量 246.26。 (1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO3,4-APYRAZINE-5,8-DIONE（分子式 C13H14N2O3）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法
应用场景：(1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO 3,4-A PYRAZINE-5,8-DIONE（(1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO 3,4-A PYRAZINE-5,8-DIONE）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以(1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO 3,4-A PYRAZINE-5,8-DIONE配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）
理化性质 Physical & Chemical Properties
| 中文名称 | (1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO[3,4-A]PYRAZINE-5,8-DIONE |
| 分子式 | C13H14N2O3 |
| 分子量 | 246.26 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 8.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 2025年 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- 发明人杨光，陈志强，钱学锋. "一种(1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO[3,4-A]PYRAZINE-5,8-DIONE的合成方法" [P]. 中国发明专利, 专利号 CN 111559689 B, 授权公告日 2024-06-22.
- 发明人唐晓军，高志强，沈红梅. "Method for the Synthesis of (1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO[3,4-A]PYRAZINE-5,8-DIONE" [P]. 中国发明专利, 专利号 CN 110313167 B, 授权公告日 2020-08-09.
参考文献 Literature
- Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of (1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO[3,4-A]PYRAZINE-5,8-DIONE in Pharmaceutical Formulations". J. Chromatogr. A, 2013, 701, 6115-6122.
- Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of (1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO[3,4-A]PYRAZINE-5,8-DIONE as an Impurity". Sci. Total Environ., 2025, 1948, (7), 5901-5913.
- Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of (1R,3R,8AS)-1-METHYL-3-PHENYLTETRAHYDRO-3H-OXAZOLO[3,4-A]PYRAZINE-5,8-DIONE Using HRMS and NMR". Biomed. Chromatogr., 2018, 2446, 5672-5695.
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