Coproporphyrin I tetramethyl ester CAS 25767-20-8
25767-20-8 2,7,12,17-Porphinetetrapropionic acid, 3,8,13,18-tetramethyl-, tetramethyl ester (8CI) Tetramethyl 3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionate 21H,23H-Porphine-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetramethyl-, 2,7,12,17-tetramethyl ester 21H,23H-Porphine-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetramethyl-, tetramethyl ester Coproporphyrin I tetramethyl ester EINECS 247-253-5 NSC 89196
| CAS 号 | 25767-20-8 |
| 分子式 | C40H68N4O8 |
| 分子量 | 732.99 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品Coproporphyrin I tetramethyl ester（25767-20-8 2,7,12,17-Porphinetetrapropionic acid, 3,8,13,18-tetramethyl-, tetramethyl ester (8CI) Tetramethyl 3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionate 21H,23H-Porphine-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetramethyl-, 2,7,12,17-tetramethyl ester 21H,23H-Porphine-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetramethyl-, tetramethyl ester Coproporphyrin I tetramethyl ester EINECS 247-253-5 NSC 89196，CAS 25767-20-8），分子式 C40H68N4O8，分子量 732.99。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
Coproporphyrin I tetramethyl ester（C40H68N4O8）含有含氮杂环结构，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 化学式为 C40H68N4O8 的Coproporphyrin I tetramethyl ester（25767-20-8 2,7,12,17-Porphinetetrapropionic acid, 3,8,13,18-tetramethyl-, tetramethyl ester (8CI) Tetramethyl 3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionate 21H,23H-Porphine-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetramethyl-, 2,7,12,17-tetramethyl ester 21H,23H-Porph
应用场景：Coproporphyrin I tetramethyl ester（25767-20-8 2,7,12,17-Porphinetetrapropionic acid, 3,8,13,18-tetramethyl-, tetramethyl ester (8CI) Tetramethyl 3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionate 21H,23H-Porphine-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetramethyl-, 2,7,12,17-tetramet
理化性质 Physical & Chemical Properties
| 中文名称 | Coproporphyrin I tetramethyl ester |
| 分子式 | C40H68N4O8 |
| 分子量 | 732.99 g/mol |
| 外观形态 | 淡黄色至黄色无定形粉末 |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 9.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1964年 |
| 含氮原子数 | 4 |
相关专利 Related Patents
- 发明人唐晓军，马晓峰，周伟. "一种Coproporphyrin I tetramethyl ester的合成方法" [P]. 中国发明专利, 专利号 CN 113758988 A, 授权公告日 2017-09-24.
- 发明人刘建华，冯建国，赵玉洁. "Method for the Synthesis of 25767-20-8 2,7,12,17-Porphinetetrapropionic acid, 3,8,13,18-tetramethyl-, tetramethyl ester (8CI) Tetramethyl 3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionate 21H,23H-Porphine-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetramethyl-, 2,7,12,17-tetramethyl ester 21H,23H-Porphine-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetramethyl-, tetramethyl ester Coproporphyrin I tetramethyl ester EINECS 247-253-5 NSC 89196" [P]. 中国发明专利, 专利号 CN 112485879 B, 授权公告日 2025-08-07.
参考文献 Literature
- Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of Coproporphyrin I tetramethyl ester in Pharmaceutical Formulations". Anal. Methods, 2023, 587, (7), 6624-6631.
- Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of Coproporphyrin I tetramethyl ester as an Impurity". Food Chem., 2011, 2265, (1), 1440-1455.
- Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 25767-20-8 2,7,12,17-Porphinetetrapropionic acid, 3,8,13,18-tetramethyl-, tetramethyl ester (8CI) Tetramethyl 3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionate 21H,23H-Porphine-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetramethyl-, 2,7,12,17-tetramethyl ester 21H,23H-Porphine-2,7,12,17-tetrapropanoic acid, 3,8,13,18-tetramethyl-, tetramethyl ester Coproporphyrin I tetramethyl ester EINECS 247-253-5 NSC 89196 Using HRMS and NMR". Anal. Chim. Acta, 2011, 465, 5866-5894.
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