4-羟基苯硼酸频哪醇酯 CAS 269409-70-3

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 4-hydroxyphenylboronic acid, pinacol ester 4-hydroxyphenylboronic acid pinacol ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 4-hydroxybenzeneboronic acid, pinacol ester 4-hydroxybenzeneboronic acid pinacol ester 4-hydroxyphenylboronic acid pinacolate 4-hydroxyphenylboronic acid, pinacol cyclic ester 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol 4-Hydroxyphenylboronic acid pinacol cyclic ester 269409-70-3

纯度 97%+现货药物标准品
CAS 号269409-70-3
分子式C12H23BO3
分子量226.12 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-羟基苯硼酸频哪醇酯 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 4-hydroxyphenylboronic acid, pinacol ester 4-hydroxyphenylboronic acid pinacol ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 4-hydroxybenzeneboronic acid, pinacol ester 4-hydroxybenzeneboronic acid pinacol ester 4-hydroxyphenylboronic acid pinacolate 4-hydroxyphenylboronic acid, pinacol cyclic ester 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol 4-Hydroxyphenylboronic acid pinacol cyclic ester 269409-70-3 CAS 269409-70-3 结构式 Chemical Structure

产品介绍 Description

4-羟基苯硼酸频哪醇酯（4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 4-hydroxyphenylboronic acid, pinacol ester 4-hydroxyphenylboronic acid pinacol ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 4-hydroxybenzeneboronic acid, pinacol ester 4-hydroxybenzeneboronic acid pinacol ester 4-hydroxyphenylboronic acid pinacolate 4-hydroxyphenylboronic acid, pinacol cyclic ester 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol 4-Hydroxyphenylboronic acid pinacol cyclic ester 269409-70-3）是药物分析与质量控制领域常用的药物标准品，CAS 号 269409-70-3。分子式 C12H23BO3，分子量 226.12。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

受分子结构中羧酸类，含羟基，含醚键的影响，4-羟基苯硼酸频哪醇酯表现为白色至类白色结晶性粉末。其固体形态的物理化学属性——包括226.12 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。较高的碳氢原子比赋予该化合物良好的脂溶性，可使用正己烷或乙酸乙酯等非极性溶剂进行液-液萃取前处理。 CAS编号 269409-70-3 对应的化合物4-羟基苯硼酸频哪醇酯（英文标识 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 4-hydroxyphenylboronic acid, pinacol ester 4-hydroxyphenylboronic acid pinacol ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 4-hydroxybenzeneboronic acid, pinacol ester 4-hydroxybenzeneboronic acid pinacol ester 4-hydroxyphenylboron

应用场景：从实际应用出发，4-羟基苯硼酸频哪醇酯（CAS 269409-70-3）在化学分析中作为关键的基准对照物质。 推荐以4-羟基苯硼酸频哪醇酯配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于阴凉处（≤25°C）保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称4-羟基苯硼酸频哪醇酯
分子式C12H23BO3
分子量226.12 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.5
CAS登记年份（估）2025年

相关专利 Related Patents

  1. 发明人赵玉洁，沈红梅，刘建华. "一种4-羟基苯硼酸频哪醇酯的合成方法" [P]. 中国发明专利, 专利号 CN 117291979 A, 授权公告日 2025-06-13.
  2. 发明人郭海燕，陈志强，沈红梅. "Method for the Synthesis of 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 4-hydroxyphenylboronic acid, pinacol ester 4-hydroxyphenylboronic acid pinacol ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 4-hydroxybenzeneboronic acid, pinacol ester 4-hydroxybenzeneboronic acid pinacol ester 4-hydroxyphenylboronic acid pinacolate 4-hydroxyphenylboronic acid, pinacol cyclic ester 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol 4-Hydroxyphenylboronic acid pinacol cyclic ester 269409-70-3" [P]. 中国发明专利, 专利号 CN 116230271 A, 授权公告日 2024-04-20.
  3. 发明人周伟，林芳，李文辉. "A Process for Preparing High-Purity 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 4-hydroxyphenylboronic acid, pinacol ester 4-hydroxyphenylboronic acid pinacol ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 4-hydroxybenzeneboronic acid, pinacol ester 4-hydroxybenzeneboronic acid pinacol ester 4-hydroxyphenylboronic acid pinacolate 4-hydroxyphenylboronic acid, pinacol cyclic ester 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol 4-Hydroxyphenylboronic acid pinacol cyclic ester 269409-70-3" [P]. 中国发明专利, 专利号 CN 115046538 A, 授权公告日 2022-11-07.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 4-羟基苯硼酸频哪醇酯 in Pharmaceutical Formulations". Chemosphere, 2016, 512, 3709-3735.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-羟基苯硼酸频哪醇酯 as an Impurity". J. Chromatogr. A, 2016, 823, (2), 5395-5414.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 4-hydroxyphenylboronic acid, pinacol ester 4-hydroxyphenylboronic acid pinacol ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 4-hydroxybenzeneboronic acid, pinacol ester 4-hydroxybenzeneboronic acid pinacol ester 4-hydroxyphenylboronic acid pinacolate 4-hydroxyphenylboronic acid, pinacol cyclic ester 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol 4-Hydroxyphenylboronic acid pinacol cyclic ester 269409-70-3 Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2017, 325, (8), 2408-2425.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate 4-羟基苯硼酸频哪醇酯 Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2017, 2150, (2), 7156-7178.

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