CAS 2765424-49-3

(4S)-4-[({2-[({2-[2-({[({[(1R,8S,9R)-bicyclo[6.1.0]non-4-yn-9-yl]methoxy}carbonyl)amino]sulfonyl}amino)ethoxy]ethoxy}carbonyl)[2-({[(1S)-3-carboxy-1-{[(1S)-1-{[(1S)-1-({4-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}oxy)methyl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}propyl]carbamoyl}oxy)ethyl]amino]ethoxy}carbonyl)amino]-4-{[(1S)-1-{[(1S)-1-({4-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}oxy)methyl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}butanoic acid

纯度 97%+现货药物标准品
CAS 号2765424-49-3
分子式C112H129F2N17O33S
分子量2311.38 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(4S)-4-[({2-[({2-[2-({[({[(1R,8S,9R)-bicyclo[6.1.0]non-4-yn-9-yl]methoxy}carbonyl)amino]sulfonyl}amino)ethoxy]ethoxy}carbonyl)[2-({[(1S)-3-carboxy-1-{[(1S)-1-{[(1S)-1-({4-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}oxy)methyl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}propyl]carbamoyl}oxy)ethyl]amino]ethoxy}carbonyl)amino]-4-{[(1S)-1-{[(1S)-1-({4-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}oxy)methyl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}butanoic acid CAS 2765424-49-3 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的（(4S)-4-[({2-[({2-[2-({[({[(1R,8S,9R)-bicyclo[6.1.0]non-4-yn-9-yl]methoxy}carbonyl)amino]sulfonyl}amino)ethoxy]ethoxy}carbonyl)[2-({[(1S)-3-carboxy-1-{[(1S)-1-{[(1S)-1-({4-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}oxy)methyl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}propyl]carbamoyl}oxy)ethyl]amino]ethoxy}carbonyl)amino]-4-{[(1S)-1-{[(1S)-1-({4-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}oxy)methyl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}butanoic acid）为药物标准品，CAS 登记号 2765424-49-3，分子式 C112H129F2N17O33S，分子量 2311.38。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

CAS编号 2765424-49-3 对应的化合物（英文标识 (4S)-4-({2-({2-2-({({(1R,8S,9R)-bicyclo6.1.0non-4-yn-9-ylmethoxy}carbonyl)aminosulfonyl}amino)ethoxyethoxy}carbonyl)2-({(1S)-3-carboxy-1-{(1S)-1-{(1S)-1-({4-({(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-ylcarbamoyl}oxy)methylphenyl}carbamoyl)ethylcarbamoyl}-2-methylpropylcarbamoyl}propylcarbamoyl}oxy)ethylaminoethoxy}carbo

应用场景：（(4S)-4- ({2- ({2- 2-({ ({ (1R,8S,9R)-bicyclo 6.1.0 non-4-yn-9-yl methoxy}carbonyl)amino sulfonyl}amino)ethoxy ethoxy}carbonyl) 2-({ (1S)-3-carboxy-1-{ (1S)-1-{ (1S)-1-({4- ({ (10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo 14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴ tetrac

理化性质 Physical & Chemical Properties

中文名称
分子式C112H129F2N17O33S
分子量2311.38 g/mol
外观形态淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）56.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2003年
卤素含量F取代
含氮原子数17
含硫原子数1

相关专利 Related Patents

  1. 发明人郭海燕，冯建国，唐晓军. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 110215765 A, 授权公告日 2015-01-25.
  2. 发明人林芳，唐晓军，周伟. "Method for the Synthesis of (4S)-4-[({2-[({2-[2-({[({[(1R,8S,9R)-bicyclo[6.1.0]non-4-yn-9-yl]methoxy}carbonyl)amino]sulfonyl}amino)ethoxy]ethoxy}carbonyl)[2-({[(1S)-3-carboxy-1-{[(1S)-1-{[(1S)-1-({4-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}oxy)methyl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}propyl]carbamoyl}oxy)ethyl]amino]ethoxy}carbonyl)amino]-4-{[(1S)-1-{[(1S)-1-({4-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}oxy)methyl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}butanoic acid" [P]. 中国发明专利, 专利号 CN 112504809 B, 授权公告日 2016-06-01.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Chromatogr. A, 2016, 1055, (6), 9414-9428.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Sci. Total Environ., 2024, 1831, (10), 3193-3197.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of (4S)-4-[({2-[({2-[2-({[({[(1R,8S,9R)-bicyclo[6.1.0]non-4-yn-9-yl]methoxy}carbonyl)amino]sulfonyl}amino)ethoxy]ethoxy}carbonyl)[2-({[(1S)-3-carboxy-1-{[(1S)-1-{[(1S)-1-({4-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}oxy)methyl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}propyl]carbamoyl}oxy)ethyl]amino]ethoxy}carbonyl)amino]-4-{[(1S)-1-{[(1S)-1-({4-[({[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamoyl}oxy)methyl]phenyl}carbamoyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}butanoic acid Using HRMS and NMR". J. Sep. Sci., 2010, 1860, 4511-4532.

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