5-氯噻吩-2-磺酰氯 CAS 2766-74-7

5-Chlorothiophene-2-sulfonyl chloride 5-chlorothiophenesulfonyl chloride 5-chloro-2-thiophenesulfonyl chloride 5-chlorothiophene-2-sulphonyl chloride 5-chlorothiophene-2-sulphonylchloride 5-chlorothiophenesulphonyl chloride 5-chlorothiophen-2-sulfonyl chloride 5-chloro-2-thienylsulfonyl chloride 5-chloro-thiophene-2-sulfonyl chloride 5-chlorothiophene-2-sulfonylchloride 2766-74-7

纯度 97%+现货药物标准品
CAS 号2766-74-7
分子式C4H6Cl2O2S2
分子量221.13 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-氯噻吩-2-磺酰氯 5-Chlorothiophene-2-sulfonyl chloride 5-chlorothiophenesulfonyl chloride 5-chloro-2-thiophenesulfonyl chloride 5-chlorothiophene-2-sulphonyl chloride 5-chlorothiophene-2-sulphonylchloride 5-chlorothiophenesulphonyl chloride 5-chlorothiophen-2-sulfonyl chloride 5-chloro-2-thienylsulfonyl chloride 5-chloro-thiophene-2-sulfonyl chloride 5-chlorothiophene-2-sulfonylchloride 2766-74-7 CAS 2766-74-7 结构式 Chemical Structure

产品介绍 Description

CAS 2766-74-7 对应的5-氯噻吩-2-磺酰氯（5-Chlorothiophene-2-sulfonyl chloride 5-chlorothiophenesulfonyl chloride 5-chloro-2-thiophenesulfonyl chloride 5-chlorothiophene-2-sulphonyl chloride 5-chlorothiophene-2-sulphonylchloride 5-chlorothiophenesulphonyl chloride 5-chlorothiophen-2-sulfonyl chloride 5-chloro-2-thienylsulfonyl chloride 5-chloro-thiophene-2-sulfonyl chloride 5-chlorothiophene-2-sulfonylchloride 2766-74-7）为 CATO 佳途药物标准品产品线成员。分子式 C4H6Cl2O2S2，分子量 221.13。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，5-氯噻吩-2-磺酰氯的分子量为221.13 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 5-氯噻吩-2-磺酰氯（5-Chlorothiophene-2-sulfonyl chloride 5-chlorothiophenesulfonyl chloride 5-chloro-2-thiophenesulfonyl chloride 5-chlorothiophene-2-sulphonyl chloride 5-chlorothiophene-2-sulphonylchloride 5-chlorothiophenesulphonyl chloride 5-chlorothiophen-2-sulfonyl chloride 5-chloro-2-thienylsulfonyl chloride 5-chloro-thiophene-2-sulfonyl chloride 5-chlorothiophene-2-sulfonylchloride 2766-74-7），CAS注册编号 2766-74-7，化学分子式为 C4H6Cl2O2

应用场景：5-氯噻吩-2-磺酰氯（5-Chlorothiophene-2-sulfonyl chloride 5-chlorothiophenesulfonyl chloride 5-chloro-2-thiophenesulfonyl chloride 5-chlorothiophene-2-sulphonyl chloride 5-chlorothiophene-2-sulphonylchloride 5-chlorothiophenesulphonyl chloride 5-chlorothiophen-2-sulfonyl chloride 5-chloro-2-thienylsulfonyl

理化性质 Physical & Chemical Properties

中文名称5-氯噻吩-2-磺酰氯
分子式C4H6Cl2O2S2
分子量221.13 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1957年
卤素含量Cl取代
含硫原子数2

相关专利 Related Patents

  1. 发明人钱学锋，韩伟，杨光. "一种5-氯噻吩-2-磺酰氯的合成方法" [P]. 中国发明专利, 专利号 CN 117574778 B, 授权公告日 2019-05-11.
  2. Lefèvre J P, Rossi M, Sørensen M. "Method for the Synthesis of 5-Chlorothiophene-2-sulfonyl chloride 5-chlorothiophenesulfonyl chloride 5-chloro-2-thiophenesulfonyl chloride 5-chlorothiophene-2-sulphonyl chloride 5-chlorothiophene-2-sulphonylchloride 5-chlorothiophenesulphonyl chloride 5-chlorothiophen-2-sulfonyl chloride 5-chloro-2-thienylsulfonyl chloride 5-chloro-thiophene-2-sulfonyl chloride 5-chlorothiophene-2-sulfonylchloride 2766-74-7" [P]. European Patent, EP 3529870 A1, 2024-09-24.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 5-氯噻吩-2-磺酰氯 in Pharmaceutical Formulations". Anal. Chim. Acta, 2015, 1404, 5294-5308.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-氯噻吩-2-磺酰氯 as an Impurity". Chromatographia, 2021, 1518, 4411-4429.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 5-Chlorothiophene-2-sulfonyl chloride 5-chlorothiophenesulfonyl chloride 5-chloro-2-thiophenesulfonyl chloride 5-chlorothiophene-2-sulphonyl chloride 5-chlorothiophene-2-sulphonylchloride 5-chlorothiophenesulphonyl chloride 5-chlorothiophen-2-sulfonyl chloride 5-chloro-2-thienylsulfonyl chloride 5-chloro-thiophene-2-sulfonyl chloride 5-chlorothiophene-2-sulfonylchloride 2766-74-7 Using HRMS and NMR". Chemosphere, 2020, 673, (5), 2793-2814.

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