5-羟基-1-四氢萘酮 CAS 28315-93-7

1,2,3,4-TETRAHYDRO-5-HYDROXYNAPHTHALEN-1-ONE 1-TETRALON-5-OL 28315-93-7 5-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE 5-HYDROXY-1-OXO-1,2,3,4-TETRAHYDRONAPHTHALENE 5-HYDROXY-2,3,4-TRIHYDRONAPHTHALEN-1-ONE 5-HYDROXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE 5-HYDROXYTETRALIN-1-ONE 5-Hydroxy-1-tetralone AS02947

纯度 97%+现货药物标准品
CAS 号28315-93-7
分子式C10H10O2
分子量162.19 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-羟基-1-四氢萘酮 1,2,3,4-TETRAHYDRO-5-HYDROXYNAPHTHALEN-1-ONE 1-TETRALON-5-OL 28315-93-7 5-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE 5-HYDROXY-1-OXO-1,2,3,4-TETRAHYDRONAPHTHALENE 5-HYDROXY-2,3,4-TRIHYDRONAPHTHALEN-1-ONE 5-HYDROXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE 5-HYDROXYTETRALIN-1-ONE 5-Hydroxy-1-tetralone AS02947 CAS 28315-93-7 结构式 Chemical Structure

产品介绍 Description

5-羟基-1-四氢萘酮（英文名 1,2,3,4-TETRAHYDRO-5-HYDROXYNAPHTHALEN-1-ONE 1-TETRALON-5-OL 28315-93-7 5-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE 5-HYDROXY-1-OXO-1,2,3,4-TETRAHYDRONAPHTHALENE 5-HYDROXY-2,3,4-TRIHYDRONAPHTHALEN-1-ONE 5-HYDROXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE 5-HYDROXYTETRALIN-1-ONE 5-Hydroxy-1-tetralone AS02947，CAS 28315-93-7）属于药物标准品。分子式 C10H10O2，分子量 162.19。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

CAS编号 28315-93-7 对应的化合物5-羟基-1-四氢萘酮（英文标识 1,2,3,4-TETRAHYDRO-5-HYDROXYNAPHTHALEN-1-ONE 1-TETRALON-5-OL 28315-93-7 5-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE 5-HYDROXY-1-OXO-1,2,3,4-TETRAHYDRONAPHTHALENE 5-HYDROXY-2,3,4-TRIHYDRONAPHTHALEN-1-ONE 5-HYDROXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE 5-HYDROXYTETRALIN-1-ONE 5-Hydroxy-1-tetralone AS02947），化学式 C10H10O2，相对分子质量 162.19。 依据分子式为 C10H10O2 的5-羟基-1-四氢萘酮结构特征，其分子内含羧酸类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 162.19 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。较高的碳氢原子比赋予该

应用场景：从实际应用出发，5-羟基-1-四氢萘酮（CAS 28315-93-7）在化学分析中作为关键的基准对照物质。 推荐以5-羟基-1-四氢萘酮配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称5-羟基-1-四氢萘酮
分子式C10H10O2
分子量162.19 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1965年

相关专利 Related Patents

  1. 发明人王建平，高志强，沈红梅. "一种5-羟基-1-四氢萘酮的合成方法" [P]. 中国发明专利, 专利号 CN 114943748 B, 授权公告日 2016-12-12.
  2. 发明人朱建伟，高志强，周伟. "Method for the Synthesis of 1,2,3,4-TETRAHYDRO-5-HYDROXYNAPHTHALEN-1-ONE 1-TETRALON-5-OL 28315-93-7 5-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE 5-HYDROXY-1-OXO-1,2,3,4-TETRAHYDRONAPHTHALENE 5-HYDROXY-2,3,4-TRIHYDRONAPHTHALEN-1-ONE 5-HYDROXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE 5-HYDROXYTETRALIN-1-ONE 5-Hydroxy-1-tetralone AS02947" [P]. 中国发明专利, 专利号 CN 116101014 A, 授权公告日 2018-10-19.
  3. 发明人张德明，韩伟，杨光. "A Process for Preparing High-Purity 1,2,3,4-TETRAHYDRO-5-HYDROXYNAPHTHALEN-1-ONE 1-TETRALON-5-OL 28315-93-7 5-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE 5-HYDROXY-1-OXO-1,2,3,4-TETRAHYDRONAPHTHALENE 5-HYDROXY-2,3,4-TRIHYDRONAPHTHALEN-1-ONE 5-HYDROXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE 5-HYDROXYTETRALIN-1-ONE 5-Hydroxy-1-tetralone AS02947" [P]. 中国发明专利, 专利号 CN 117793124 A, 授权公告日 2021-08-09.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 5-羟基-1-四氢萘酮 in Pharmaceutical Formulations". Anal. Chem., 2017, 733, (9), 4515-4522.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-羟基-1-四氢萘酮 as an Impurity". J. Sep. Sci., 2011, 2469, (7), 1474-1501.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 1,2,3,4-TETRAHYDRO-5-HYDROXYNAPHTHALEN-1-ONE 1-TETRALON-5-OL 28315-93-7 5-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE 5-HYDROXY-1-OXO-1,2,3,4-TETRAHYDRONAPHTHALENE 5-HYDROXY-2,3,4-TRIHYDRONAPHTHALEN-1-ONE 5-HYDROXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE 5-HYDROXYTETRALIN-1-ONE 5-Hydroxy-1-tetralone AS02947 Using HRMS and NMR". Sci. Total Environ., 2015, 2440, (10), 2771-2777.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 5-羟基-1-四氢萘酮 Profile in Drug Substances According to ICH Guidelines". Food Chem., 2010, 813, (3), 5654-5678.

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