2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one CAS 327085-04-1

2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one

纯度 97%+现货药物标准品
CAS 号327085-04-1
分子式C16H14F3NO
分子量293.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one CAS 327085-04-1 结构式 Chemical Structure

产品介绍 Description

2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one（英文名 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one，CAS 327085-04-1）属于药物标准品。分子式 C16H14F3NO，分子量 293.28。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，2-methyl-1-3-(trifluoromethyl)phenyl-4,5,6,7-tetrahydro-1H-indol-4-one的分子量为293.28 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C16H14F3NO 的2-methyl-1-3-(trifluoromethyl)phenyl-4,5,6,7-tetrahydro-1H-indol-4-one（2-methyl-1-3-(trifluoromethyl)phenyl-4,5,6,7-tetrahydro-1H-indol-4-one），其CAS登记号是 327085-04-1，分子量为 293.28 g/mol。 2-methyl-1-3-(trifluoromethyl)phenyl-4,5,6,7-tetrahydro-1H-indol-4-one（C16H14F3NO）含有含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代。卤素取代增加了化合物的密度和沸点，较高的碳氢比使其脂溶性较好，这些物理化学性质直接决定了其标准溶液的最佳配制

应用场景：2-methyl-1- 3-(trifluoromethyl)phenyl -4,5,6,7-tetrahydro-1H-indol-4-one（2-methyl-1- 3-(trifluoromethyl)phenyl -4,5,6,7-tetrahydro-1H-indol-4-one，CAS 327085-04-1）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以2-methyl-1- 3-(trifluoromethyl)phenyl -4,5,6,7-tetrahydro-1H-indol-4-one配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈

理化性质 Physical & Chemical Properties

中文名称2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one
分子式C16H14F3NO
分子量293.28 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
卤素含量F取代
含氮原子数1

相关专利 Related Patents

  1. Patel M V, Park J H, Davis P L. "一种2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one的合成方法" [P]. US Patent, US 9515475 B2, 2019-11-17.
  2. Björnsson E, Nowak P, Nielsen H. "Method for the Synthesis of 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one" [P]. European Patent, EP 3687427 A1, 2025-05-03.
  3. 发明人马晓峰，唐晓军，罗永刚. "A Process for Preparing High-Purity 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one" [P]. 中国发明专利, 专利号 CN 117306972 B, 授权公告日 2019-11-04.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one in Pharmaceutical Formulations". Talanta, 2015, 2000, (8), 2690-2695.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one as an Impurity". J. Agric. Food Chem., 2020, 2136, (1), 1678-1705.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2019, 456, (10), 4321-4344.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-one Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2014, 193, (1), 8069-8088.

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