<I>N</I>-叔丁基-α-苯基硝酮 CAS 3376-24-7

3376-24-7 Phenyl-N-tert-butylnitrone N-Benzyliden-tert-butylamine N-ether Nitrone, N-tert-butyl-alpha-phenyl- (6CI,7CI,8CI) S-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide tert Butylphenylnitrone Benzylidene-tert-butylamine N-oxide N-tert-Butyl-alpha-phenylnitrone N-tert-Butyl-C-phenylnitrone N-tert-Butyl-2-phenylnitrone EINECS 222-168-6 2-Methyl-N-(phenylmethylene)-S-propanamine N-oxide PBN alpha-Phenyl-t-butylnitrone C-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-t-butylnitrone 2-Phenyl-N-tert-butylnitrone

纯度 97%+现货药物标准品
CAS 号3376-24-7
分子式C11H21NO
分子量183.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

<I>N</I>-叔丁基-α-苯基硝酮 3376-24-7 Phenyl-N-tert-butylnitrone N-Benzyliden-tert-butylamine N-ether Nitrone, N-tert-butyl-alpha-phenyl- (6CI,7CI,8CI) S-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide tert Butylphenylnitrone Benzylidene-tert-butylamine N-oxide N-tert-Butyl-alpha-phenylnitrone N-tert-Butyl-C-phenylnitrone N-tert-Butyl-2-phenylnitrone EINECS 222-168-6 2-Methyl-N-(phenylmethylene)-S-propanamine N-oxide PBN alpha-Phenyl-t-butylnitrone C-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-t-butylnitrone 2-Phenyl-N-tert-butylnitrone CAS 3376-24-7 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品<I>N</I>-叔丁基-α-苯基硝酮（3376-24-7 Phenyl-N-tert-butylnitrone N-Benzyliden-tert-butylamine N-ether Nitrone, N-tert-butyl-alpha-phenyl- (6CI,7CI,8CI) S-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide tert Butylphenylnitrone Benzylidene-tert-butylamine N-oxide N-tert-Butyl-alpha-phenylnitrone N-tert-Butyl-C-phenylnitrone N-tert-Butyl-2-phenylnitrone EINECS 222-168-6 2-Methyl-N-(phenylmethylene)-S-propanamine N-oxide PBN alpha-Phenyl-t-butylnitrone C-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-t-butylnitrone 2-Phenyl-N-tert-butylnitrone，CAS 3376-24-7），分子式 C11H21NO，分子量 183.29。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，<I>N</I>-叔丁基-α-苯基硝酮的分子量为183.29 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 3376-24-7 对应的化合物<I>N</I>-叔丁基-α-苯基硝酮（英文标识 3376-24-7 Phenyl-N-tert-butylnitrone N-Benzyliden-tert-butylamine N-ether Nitrone, N-tert-butyl-alpha-phenyl- (6CI,7CI,8CI) S-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide tert Butylphenylnitrone Benzylidene-tert-butylamine N-oxide N-tert-Butyl-alpha-phenylnitrone N-tert-Butyl-C-phenylnitrone N-tert-Butyl-2-phenyl

应用场景：在化学分析实验室中，<I>N</I>-叔丁基-α-苯基硝酮（CAS 3376-24-7）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以<I>N</I>-叔丁基-α-苯基硝酮配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽

理化性质 Physical & Chemical Properties

中文名称<I>N</I>-叔丁基-α-苯基硝酮
分子式C11H21NO
分子量183.29 g/mol
外观形态白色至类白色低熔点固体
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1957年
含氮原子数1

相关专利 Related Patents

  1. 发明人钱学锋，张德明，赵玉洁. "一种<I>N</I>-叔丁基-α-苯基硝酮的合成方法" [P]. 中国发明专利, 专利号 CN 110533869 B, 授权公告日 2020-03-28.
  2. Fischer A B, Brown S R, Hughes D C. "Method for the Synthesis of 3376-24-7 Phenyl-N-tert-butylnitrone N-Benzyliden-tert-butylamine N-ether Nitrone, N-tert-butyl-alpha-phenyl- (6CI,7CI,8CI) S-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide tert Butylphenylnitrone Benzylidene-tert-butylamine N-oxide N-tert-Butyl-alpha-phenylnitrone N-tert-Butyl-C-phenylnitrone N-tert-Butyl-2-phenylnitrone EINECS 222-168-6 2-Methyl-N-(phenylmethylene)-S-propanamine N-oxide PBN alpha-Phenyl-t-butylnitrone C-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-t-butylnitrone 2-Phenyl-N-tert-butylnitrone" [P]. US Patent, US 10385667 B2, 2022-12-16.
  3. 发明人罗永刚，韩伟，冯建国. "A Process for Preparing High-Purity 3376-24-7 Phenyl-N-tert-butylnitrone N-Benzyliden-tert-butylamine N-ether Nitrone, N-tert-butyl-alpha-phenyl- (6CI,7CI,8CI) S-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide tert Butylphenylnitrone Benzylidene-tert-butylamine N-oxide N-tert-Butyl-alpha-phenylnitrone N-tert-Butyl-C-phenylnitrone N-tert-Butyl-2-phenylnitrone EINECS 222-168-6 2-Methyl-N-(phenylmethylene)-S-propanamine N-oxide PBN alpha-Phenyl-t-butylnitrone C-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-t-butylnitrone 2-Phenyl-N-tert-butylnitrone" [P]. 中国发明专利, 专利号 CN 115369683 B, 授权公告日 2020-12-18.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of <I>N</I>-叔丁基-α-苯基硝酮 in Pharmaceutical Formulations". Chromatographia, 2015, 359, 7071-7100.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>N</I>-叔丁基-α-苯基硝酮 as an Impurity". Rapid Commun. Mass Spectrom., 2010, 1260, (3), 9805-9825.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 3376-24-7 Phenyl-N-tert-butylnitrone N-Benzyliden-tert-butylamine N-ether Nitrone, N-tert-butyl-alpha-phenyl- (6CI,7CI,8CI) S-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide tert Butylphenylnitrone Benzylidene-tert-butylamine N-oxide N-tert-Butyl-alpha-phenylnitrone N-tert-Butyl-C-phenylnitrone N-tert-Butyl-2-phenylnitrone EINECS 222-168-6 2-Methyl-N-(phenylmethylene)-S-propanamine N-oxide PBN alpha-Phenyl-t-butylnitrone C-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-tert-butylnitrone alpha-Phenyl-N-t-butylnitrone 2-Phenyl-N-tert-butylnitrone Using HRMS and NMR". Talanta, 2011, 1569, (7), 7701-7729.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate <I>N</I>-叔丁基-α-苯基硝酮 Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2016, 1285, (9), 316-344.

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