间苯二酚蓝 CAS 33869-21-5
33869-21-5 7-Amino-8-(2,4-dihydroxyphenyl)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one--8-(2,4-dihydroxyphenyl)-7-hydroxy-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one (1/1) DTXSID70657601
| CAS 号 | 33869-21-5 |
| 分子式 | C24H34N2O6 |
| 分子量 | 446.54 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CATO 佳途供应的间苯二酚蓝（33869-21-5 7-Amino-8-(2,4-dihydroxyphenyl)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one--8-(2,4-dihydroxyphenyl)-7-hydroxy-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one (1/1) DTXSID70657601）为药物标准品，CAS 登记号 33869-21-5，分子式 C24H34N2O6，分子量 446.54。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。
间苯二酚蓝（C24H34N2O6）含有黄酮骨架，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 间苯二酚蓝（33869-21-5 7-Amino-8-(2,4-dihydroxyphenyl)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one--8-(2,4-dihydroxyphenyl)-7-hydroxy-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one (1/1) DTXSID70657601），CAS注册编号 33869-21-5，化学分子式为 C24H34N2O6，分子量 446.54 g/mol。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台
应用场景：间苯二酚蓝（33869-21-5 7-Amino-8-(2,4-dihydroxyphenyl)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one--8-(2,4-dihydroxyphenyl)-7-hydroxy-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one (1/1) DTXSID70657601）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以间苯
理化性质 Physical & Chemical Properties
| 中文名称 | 间苯二酚蓝 |
| 分子式 | C24H34N2O6 |
| 分子量 | 446.54 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 9.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1966年 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- 发明人林芳，郑宇鹏，马晓峰. "一种间苯二酚蓝的合成方法" [P]. 中国发明专利, 专利号 CN 117705161 A, 授权公告日 2015-02-28.
- 发明人何建平，罗永刚，朱建伟. "Method for the Synthesis of 33869-21-5 7-Amino-8-(2,4-dihydroxyphenyl)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one--8-(2,4-dihydroxyphenyl)-7-hydroxy-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one (1/1) DTXSID70657601" [P]. 中国发明专利, 专利号 CN 109346234 A, 授权公告日 2016-12-01.
参考文献 Literature
- Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 间苯二酚蓝 in Pharmaceutical Formulations". Anal. Chem., 2017, 1338, 3768-3793.
- Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 间苯二酚蓝 as an Impurity". J. Agric. Food Chem., 2022, 912, (5), 5712-5738.
- Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 33869-21-5 7-Amino-8-(2,4-dihydroxyphenyl)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one--8-(2,4-dihydroxyphenyl)-7-hydroxy-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-2,10-dihydro-3H-phenoxazin-3-one (1/1) DTXSID70657601 Using HRMS and NMR". Molecules, 2017, 558, 2282-2304.
- Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate 间苯二酚蓝 Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2022, 1390, (1), 2985-2988.
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