6-氟吡啶-3-硼酸 CAS 351019-18-6
(2-FLUORO-5-PYRIDINYL)-BORONIC ACID 2-FLUORO-5-PYRIDINEBORONIC ACID 2-FLUORO-5-PYRIDYLBORONIC ACID 2-FLUOROPYRIDIN-5-BORONIC ACID 2-FLUOROPYRIDIN-5-YLBORONIC ACID 2-FLUOROPYRIDINE-5-BORONIC ACID 351019-18-6 6-FLUORO-3-PYRIDINEBORONIC ACID 6-FLUORO-3-PYRIDINYLBORONIC ACID 6-FLUORO-3-PYRIDYLBORONIC ACID 6-FLUOROPYRIDIN-3-YL-3-BORONIC ACID 6-FLUOROPYRIDIN-3-YLBORONIC ACID 6-FLUOROPYRIDINE-3-BORONIC ACID ABBYPHARMA AP-15-5198 BORONIC ACID, (6-FLUORO-3-PYRIDINYL)- BORONIC ACID, B-(6-FLUORO-2-PYRIDINYL)- Boronic acid, B-(6-fluoro-3-pyridinyl)- NF10318 PYRIDINE 2-FLUORO-5-BORONIC ACID
| CAS 号 | 351019-18-6 |
| 分子式 | C5H11BFNO2 |
| 分子量 | 146.96 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CATO 佳途供应的6-氟吡啶-3-硼酸（(2-FLUORO-5-PYRIDINYL)-BORONIC ACID 2-FLUORO-5-PYRIDINEBORONIC ACID 2-FLUORO-5-PYRIDYLBORONIC ACID 2-FLUOROPYRIDIN-5-BORONIC ACID 2-FLUOROPYRIDIN-5-YLBORONIC ACID 2-FLUOROPYRIDINE-5-BORONIC ACID 351019-18-6 6-FLUORO-3-PYRIDINEBORONIC ACID 6-FLUORO-3-PYRIDINYLBORONIC ACID 6-FLUORO-3-PYRIDYLBORONIC ACID 6-FLUOROPYRIDIN-3-YL-3-BORONIC ACID 6-FLUOROPYRIDIN-3-YLBORONIC ACID 6-FLUOROPYRIDINE-3-BORONIC ACID ABBYPHARMA AP-15-5198 BORONIC ACID, (6-FLUORO-3-PYRIDINYL)- BORONIC ACID, B-(6-FLUORO-2-PYRIDINYL)- Boronic acid, B-(6-fluoro-3-pyridinyl)- NF10318 PYRIDINE 2-FLUORO-5-BORONIC ACID）为药物标准品，CAS 登记号 351019-18-6，分子式 C5H11BFNO2，分子量 146.96。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。
化学式为 C5H11BFNO2 的6-氟吡啶-3-硼酸（(2-FLUORO-5-PYRIDINYL)-BORONIC ACID 2-FLUORO-5-PYRIDINEBORONIC ACID 2-FLUORO-5-PYRIDYLBORONIC ACID 2-FLUOROPYRIDIN-5-BORONIC ACID 2-FLUOROPYRIDIN-5-YLBORONIC ACID 2-FLUOROPYRIDINE-5-BORONIC ACID 351019-18-6 6-FLUORO-3-PYRIDINEBORONIC ACID 6-FLUORO-3-PYRIDINYLBORONIC ACID 6-FLUORO-3-PYRIDYLBORONIC ACID 6-FLUOROPYRIDIN-3-YL-3-BORONIC ACID 6-FLUOROPYRIDIN-3-YLBORONIC ACID 6-FLUOROPYRIDINE-3-BORONIC ACID ABBYPHARMA AP-15-5198 BORONIC ACID, (6-FLUORO-3-PYRIDINYL)- BORONIC
应用场景：从实际应用出发，6-氟吡啶-3-硼酸（CAS 351019-18-6）在化学分析中作为关键的基准对照物质。 推荐以6-氟吡啶-3-硼酸配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密闭保存防止挥发条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | 6-氟吡啶-3-硼酸 |
| 分子式 | C5H11BFNO2 |
| 分子量 | 146.96 g/mol |
| 外观形态 | 白色至类白色液体。（具有轻微卤代物特征气味，具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 对光敏感，应避免强光直射；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 0.5 |
| CAS登记年份（估） | 2025年 |
| 卤素含量 | F取代 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人陈志强，刘建华，沈红梅. "一种6-氟吡啶-3-硼酸的合成方法" [P]. 中国发明专利, 专利号 CN 116716472 A, 授权公告日 2017-05-03.
- Chen K W, Johnson M A, Lee S K. "Method for the Synthesis of (2-FLUORO-5-PYRIDINYL)-BORONIC ACID 2-FLUORO-5-PYRIDINEBORONIC ACID 2-FLUORO-5-PYRIDYLBORONIC ACID 2-FLUOROPYRIDIN-5-BORONIC ACID 2-FLUOROPYRIDIN-5-YLBORONIC ACID 2-FLUOROPYRIDINE-5-BORONIC ACID 351019-18-6 6-FLUORO-3-PYRIDINEBORONIC ACID 6-FLUORO-3-PYRIDINYLBORONIC ACID 6-FLUORO-3-PYRIDYLBORONIC ACID 6-FLUOROPYRIDIN-3-YL-3-BORONIC ACID 6-FLUOROPYRIDIN-3-YLBORONIC ACID 6-FLUOROPYRIDINE-3-BORONIC ACID ABBYPHARMA AP-15-5198 BORONIC ACID, (6-FLUORO-3-PYRIDINYL)- BORONIC ACID, B-(6-FLUORO-2-PYRIDINYL)- Boronic acid, B-(6-fluoro-3-pyridinyl)- NF10318 PYRIDINE 2-FLUORO-5-BORONIC ACID" [P]. US Patent, US 11976638 B2, 2015-07-25.
参考文献 Literature
- Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 6-氟吡啶-3-硼酸 in Pharmaceutical Formulations". Phytochemistry, 2020, 479, 5828-5853.
- Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-氟吡啶-3-硼酸 as an Impurity". Biomed. Chromatogr., 2022, 1084, 2947-2976.
- Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of (2-FLUORO-5-PYRIDINYL)-BORONIC ACID 2-FLUORO-5-PYRIDINEBORONIC ACID 2-FLUORO-5-PYRIDYLBORONIC ACID 2-FLUOROPYRIDIN-5-BORONIC ACID 2-FLUOROPYRIDIN-5-YLBORONIC ACID 2-FLUOROPYRIDINE-5-BORONIC ACID 351019-18-6 6-FLUORO-3-PYRIDINEBORONIC ACID 6-FLUORO-3-PYRIDINYLBORONIC ACID 6-FLUORO-3-PYRIDYLBORONIC ACID 6-FLUOROPYRIDIN-3-YL-3-BORONIC ACID 6-FLUOROPYRIDIN-3-YLBORONIC ACID 6-FLUOROPYRIDINE-3-BORONIC ACID ABBYPHARMA AP-15-5198 BORONIC ACID, (6-FLUORO-3-PYRIDINYL)- BORONIC ACID, B-(6-FLUORO-2-PYRIDINYL)- Boronic acid, B-(6-fluoro-3-pyridinyl)- NF10318 PYRIDINE 2-FLUORO-5-BORONIC ACID Using HRMS and NMR". J. Chromatogr. A, 2015, 228, 5617-5625.
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