2,4-二甲基-5-乙酰基噻唑 CAS 38205-60-6

PD36FU2WGY 38205-60-6 2,4-Dimethyl-5-acetylthiazole 1-(2,4-Dimethylthiazol-5-yl)ethan-1-one Ethanone, 1-(2,4-dimethyl-5-thiazolyl)- 5-Acetyl-2,4-dimethylthiazole 1-(2,4-Dimethyl-5-thiazolyl)ethanone 2,4-Dimethyl-5-thiazoyl methyl ketone EINECS 253-826-0 FEMA No. 3267 Ketone, 2,4-dimethyl-5-thiazolyl methyl UNII-PD36FU2WGY

纯度 97%+现货药物标准品
CAS 号38205-60-6
分子式C7H13NOS
分子量159.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2,4-二甲基-5-乙酰基噻唑 PD36FU2WGY 38205-60-6 2,4-Dimethyl-5-acetylthiazole 1-(2,4-Dimethylthiazol-5-yl)ethan-1-one Ethanone, 1-(2,4-dimethyl-5-thiazolyl)- 5-Acetyl-2,4-dimethylthiazole 1-(2,4-Dimethyl-5-thiazolyl)ethanone 2,4-Dimethyl-5-thiazoyl methyl ketone EINECS 253-826-0 FEMA No. 3267 Ketone, 2,4-dimethyl-5-thiazolyl methyl UNII-PD36FU2WGY CAS 38205-60-6 结构式 Chemical Structure

产品介绍 Description

2,4-二甲基-5-乙酰基噻唑（PD36FU2WGY 38205-60-6 2,4-Dimethyl-5-acetylthiazole 1-(2,4-Dimethylthiazol-5-yl)ethan-1-one Ethanone, 1-(2,4-dimethyl-5-thiazolyl)- 5-Acetyl-2,4-dimethylthiazole 1-(2,4-Dimethyl-5-thiazolyl)ethanone 2,4-Dimethyl-5-thiazoyl methyl ketone EINECS 253-826-0 FEMA No. 3267 Ketone, 2,4-dimethyl-5-thiazolyl methyl UNII-PD36FU2WGY）是药物分析与质量控制领域常用的药物标准品，CAS 号 38205-60-6。分子式 C7H13NOS，分子量 159.25。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，2,4-二甲基-5-乙酰基噻唑的分子量为159.25 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 2,4-二甲基-5-乙酰基噻唑（PD36FU2WGY 38205-60-6 2,4-Dimethyl-5-acetylthiazole 1-(2,4-Dimethylthiazol-5-yl)ethan-1-one Ethanone, 1-(2,4-dimethyl-5-thiazolyl)- 5-Acetyl-2,4-dimethylthiazole 1-(2,4-Dimethyl-5-thiazolyl)ethanone 2,4-Dimethyl-5-thiazoyl methyl ketone EINECS 253-826-0 FEMA No. 3267 Ketone, 2,4-dimethyl-5-thiazolyl methyl UNII-PD36FU2WGY），CAS注册编号 38205-60-6，化学分子式为 C7H13NOS，分子量 159.25 g/mol。 2,4-二甲基-5-乙酰基噻唑（C7H13NOS）含有酰胺类，

应用场景：从实际应用出发，2,4-二甲基-5-乙酰基噻唑（CAS 38205-60-6）在化学分析中作为关键的基准对照物质。 推荐以2,4-二甲基-5-乙酰基噻唑配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称2,4-二甲基-5-乙酰基噻唑
分子式C7H13NOS
分子量159.25 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1967年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. 发明人朱建伟，唐晓军，沈红梅. "一种2,4-二甲基-5-乙酰基噻唑的合成方法" [P]. 中国发明专利, 专利号 CN 112055011 A, 授权公告日 2023-04-27.
  2. 发明人徐明华，胡光，高志强. "Method for the Synthesis of PD36FU2WGY 38205-60-6 2,4-Dimethyl-5-acetylthiazole 1-(2,4-Dimethylthiazol-5-yl)ethan-1-one Ethanone, 1-(2,4-dimethyl-5-thiazolyl)- 5-Acetyl-2,4-dimethylthiazole 1-(2,4-Dimethyl-5-thiazolyl)ethanone 2,4-Dimethyl-5-thiazoyl methyl ketone EINECS 253-826-0 FEMA No. 3267 Ketone, 2,4-dimethyl-5-thiazolyl methyl UNII-PD36FU2WGY" [P]. 中国发明专利, 专利号 CN 113156058 A, 授权公告日 2022-09-11.
  3. Lefèvre J P, Johansson L, Nowak P. "A Process for Preparing High-Purity PD36FU2WGY 38205-60-6 2,4-Dimethyl-5-acetylthiazole 1-(2,4-Dimethylthiazol-5-yl)ethan-1-one Ethanone, 1-(2,4-dimethyl-5-thiazolyl)- 5-Acetyl-2,4-dimethylthiazole 1-(2,4-Dimethyl-5-thiazolyl)ethanone 2,4-Dimethyl-5-thiazoyl methyl ketone EINECS 253-826-0 FEMA No. 3267 Ketone, 2,4-dimethyl-5-thiazolyl methyl UNII-PD36FU2WGY" [P]. European Patent, EP 3818650 A1, 2022-03-24.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 2,4-二甲基-5-乙酰基噻唑 in Pharmaceutical Formulations". J. Agric. Food Chem., 2015, 1676, 8543-8558.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2,4-二甲基-5-乙酰基噻唑 as an Impurity". Rapid Commun. Mass Spectrom., 2020, 467, 6076-6081.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of PD36FU2WGY 38205-60-6 2,4-Dimethyl-5-acetylthiazole 1-(2,4-Dimethylthiazol-5-yl)ethan-1-one Ethanone, 1-(2,4-dimethyl-5-thiazolyl)- 5-Acetyl-2,4-dimethylthiazole 1-(2,4-Dimethyl-5-thiazolyl)ethanone 2,4-Dimethyl-5-thiazoyl methyl ketone EINECS 253-826-0 FEMA No. 3267 Ketone, 2,4-dimethyl-5-thiazolyl methyl UNII-PD36FU2WGY Using HRMS and NMR". Talanta, 2016, 2398, 6786-6789.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 2,4-二甲基-5-乙酰基噻唑 Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2012, 870, (1), 4502-4522.

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