间氟三氟甲苯 CAS 401-80-9

1-(Trifluoromethyl)-3-fluorobenzene 1-Fluoro-3-(trifluoromethyl)benzene 401-80-9 Benzene, 1-fluoro-3-(trifluoromethyl)- NSC-10315 NSC10315 Toluene,.alpha.,.alpha.,.alpha.-tetrafluoro- Toluene,.alpha.,.alpha.-m-tetrafluoro- Trifluoromethyl-3-fluorobenzene m,.alpha.,.alpha.-Tetrafluorotoluene m-Fluorobenzotrifluoride

纯度 97%+现货药物标准品
CAS 号401-80-9
分子式C7H10F4
分子量170.15 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

间氟三氟甲苯 1-(Trifluoromethyl)-3-fluorobenzene 1-Fluoro-3-(trifluoromethyl)benzene 401-80-9 Benzene, 1-fluoro-3-(trifluoromethyl)- NSC-10315 NSC10315 Toluene,.alpha.,.alpha.,.alpha.-tetrafluoro- Toluene,.alpha.,.alpha.-m-tetrafluoro- Trifluoromethyl-3-fluorobenzene m,.alpha.,.alpha.-Tetrafluorotoluene m-Fluorobenzotrifluoride CAS 401-80-9 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的间氟三氟甲苯（1-(Trifluoromethyl)-3-fluorobenzene 1-Fluoro-3-(trifluoromethyl)benzene 401-80-9 Benzene, 1-fluoro-3-(trifluoromethyl)- NSC-10315 NSC10315 Toluene,.alpha.,.alpha.,.alpha.-tetrafluoro- Toluene,.alpha.,.alpha.-m-tetrafluoro- Trifluoromethyl-3-fluorobenzene m,.alpha.,.alpha.-Tetrafluorotoluene m-Fluorobenzotrifluoride）为药物标准品，CAS 登记号 401-80-9，分子式 C7H10F4，分子量 170.15。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括间氟三氟甲苯在内的目标物的控制。 化学式为 C7H10F4 的间氟三氟甲苯（1-(Trifluoromethyl)-3-fluorobenzene 1-Fluoro-3-(trifluoromethyl)benzene 401-80-9 Benzene, 1-fluoro-3-(trifluoromethyl)- NSC-10315 NSC10315 Toluene,.alpha.,.alpha.,.alpha.-tetrafluoro- Toluene,.alpha.,.alpha.-m-tetrafluoro- Trifluoromethyl-3-fluorobenzene m,.alpha.,.alpha.-Tetrafluorotoluene m-Fluorobenzotrifluoride），其CAS登记号是 401-80-9，分子量为 170.15 g/mol。 受分子结构中含氟取代的影响，间氟三氟甲苯表现为白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）。其固体形态的物理化学属性——包括170.

应用场景：针对化学分析用途，间氟三氟甲苯（1-(Trifluoromethyl)-3-fluorobenzene 1-Fluoro-3-(trifluoromethyl)benzene 401-80-9 Benzene, 1-fluoro-3-(trifluoromethyl)- NSC-10315 NSC10315 Toluene,.alpha.,.alpha.,.alpha.-tetrafluoro- Toluene,.alpha.,.alpha.-m-tetrafluoro- Trifluoromethyl-3-fluorobenzene m,.alpha.,.alpha.-Tetrafluoro

理化性质 Physical & Chemical Properties

中文名称间氟三氟甲苯
分子式C7H10F4
分子量170.15 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1957年
卤素含量F取代

相关专利 Related Patents

  1. Schröder R, Brown S R, Davis P L. "一种间氟三氟甲苯的合成方法" [P]. US Patent, US 11257514 B2, 2023-05-05.
  2. 发明人张德明，李文辉，韩伟. "Method for the Synthesis of 1-(Trifluoromethyl)-3-fluorobenzene 1-Fluoro-3-(trifluoromethyl)benzene 401-80-9 Benzene, 1-fluoro-3-(trifluoromethyl)- NSC-10315 NSC10315 Toluene,.alpha.,.alpha.,.alpha.-tetrafluoro- Toluene,.alpha.,.alpha.-m-tetrafluoro- Trifluoromethyl-3-fluorobenzene m,.alpha.,.alpha.-Tetrafluorotoluene m-Fluorobenzotrifluoride" [P]. 中国发明专利, 专利号 CN 112406742 B, 授权公告日 2020-05-18.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 间氟三氟甲苯 in Pharmaceutical Formulations". Environ. Sci. Technol., 2025, 984, (7), 3184-3207.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 间氟三氟甲苯 as an Impurity". Anal. Methods, 2018, 638, (11), 3369-3384.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 1-(Trifluoromethyl)-3-fluorobenzene 1-Fluoro-3-(trifluoromethyl)benzene 401-80-9 Benzene, 1-fluoro-3-(trifluoromethyl)- NSC-10315 NSC10315 Toluene,.alpha.,.alpha.,.alpha.-tetrafluoro- Toluene,.alpha.,.alpha.-m-tetrafluoro- Trifluoromethyl-3-fluorobenzene m,.alpha.,.alpha.-Tetrafluorotoluene m-Fluorobenzotrifluoride Using HRMS and NMR". J. Sep. Sci., 2018, 744, (12), 9064-9089.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate 间氟三氟甲苯 Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2019, 1108, (3), 5341-5354.

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