3-羟基金刚烷-1-羧酸 CAS 42711-75-1
3-Hydroxy-adamantane-1-carboxylic acid 3-hydroxyadamantancarboxylic acid 3-hydroxyadamantane-1-carboxylic acid 3-hydroxyadamantanecarboxylic acid 1-hydroxyadamantane-3-carboxylic acid 3-hydroxy-tricyclo[ (5r,7s)-3-hydroxyadamantane-1-carboxylic acid 42711-75-1
| CAS 号 | 42711-75-1 |
| 分子式 | C11H16O3 |
| 分子量 | 196.24 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 42711-75-1 对应的3-羟基金刚烷-1-羧酸（3-Hydroxy-adamantane-1-carboxylic acid 3-hydroxyadamantancarboxylic acid 3-hydroxyadamantane-1-carboxylic acid 3-hydroxyadamantanecarboxylic acid 1-hydroxyadamantane-3-carboxylic acid 3-hydroxy-tricyclo[ (5r,7s)-3-hydroxyadamantane-1-carboxylic acid 42711-75-1）为 CATO 佳途药物标准品产品线成员。分子式 C11H16O3，分子量 196.24。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
受分子结构中羧酸类，含羟基，含醚键的影响，3-羟基金刚烷-1-羧酸表现为类白色至淡黄色结晶性粉末。其固体形态的物理化学属性——包括196.24 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 3-羟基金刚烷-1-羧酸（3-Hydroxy-adamantane-1-carboxylic acid 3-hydroxyadamantancarboxylic acid 3-hydroxyadamantane-1-carboxylic acid 3-hydroxyadamantanecarboxylic acid 1-hydroxyadamantane-3-carboxylic acid 3-hydroxy-tricyclo (5r,7s)-3-hydroxyadamantane-1-carboxylic acid 42711-75-1），CAS注册编号 42711-75-1，化学分子式为 C11H16O3，分子量 196.24 g/mol。 推荐用
应用场景：3-羟基金刚烷-1-羧酸（3-Hydroxy-adamantane-1-carboxylic acid 3-hydroxyadamantancarboxylic acid 3-hydroxyadamantane-1-carboxylic acid 3-hydroxyadamantanecarboxylic acid 1-hydroxyadamantane-3-carboxylic acid 3-hydroxy-tricyclo (5r,7s)-3-hydroxyadamantane-1-carboxylic acid 42711-75-1，CAS 42711-75-1）的标准化应用场景涵盖化
理化性质 Physical & Chemical Properties
| 中文名称 | 3-羟基金刚烷-1-羧酸 |
| 分子式 | C11H16O3 |
| 分子量 | 196.24 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 4.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1969年 |
相关专利 Related Patents
- 发明人徐明华，杨光，胡光. "一种3-羟基金刚烷-1-羧酸的合成方法" [P]. 中国发明专利, 专利号 CN 110628495 A, 授权公告日 2019-07-20.
- 发明人刘建华，高志强，韩伟. "Method for the Synthesis of 3-Hydroxy-adamantane-1-carboxylic acid 3-hydroxyadamantancarboxylic acid 3-hydroxyadamantane-1-carboxylic acid 3-hydroxyadamantanecarboxylic acid 1-hydroxyadamantane-3-carboxylic acid 3-hydroxy-tricyclo[ (5r,7s)-3-hydroxyadamantane-1-carboxylic acid 42711-75-1" [P]. 中国发明专利, 专利号 CN 114488147 A, 授权公告日 2021-01-01.
参考文献 Literature
- Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 3-羟基金刚烷-1-羧酸 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2014, 1420, 2623-2639.
- Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-羟基金刚烷-1-羧酸 as an Impurity". Phytochemistry, 2014, 2246, (11), 7163-7193.
- Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 3-Hydroxy-adamantane-1-carboxylic acid 3-hydroxyadamantancarboxylic acid 3-hydroxyadamantane-1-carboxylic acid 3-hydroxyadamantanecarboxylic acid 1-hydroxyadamantane-3-carboxylic acid 3-hydroxy-tricyclo[ (5r,7s)-3-hydroxyadamantane-1-carboxylic acid 42711-75-1 Using HRMS and NMR". Food Chem., 2024, 1695, 2292-2311.
- Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate 3-羟基金刚烷-1-羧酸 Profile in Drug Substances According to ICH Guidelines". Talanta, 2013, 277, (8), 7186-7209.
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