2-氨甲基-1,4-苯并二噁烷 CAS 4442-59-5

(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amine (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanamine 1-(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine 2-(Aminomethyl)benzodioxan 2-aminomethyl-1,4-benzodioxan 2-aminomethyl-1,4-benzodioxane 2-aminomethyl-2,3-dihydro-benzo[1,4]dioxine 2-aminomethylbenzodioxan 2-aminomethylbenzodioxane 4442-59-5 c-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-methylamine

纯度 97%+现货药物标准品
CAS 号4442-59-5
分子式C9H17NO2
分子量171.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-氨甲基-1,4-苯并二噁烷 (2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amine (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanamine 1-(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine 2-(Aminomethyl)benzodioxan 2-aminomethyl-1,4-benzodioxan 2-aminomethyl-1,4-benzodioxane 2-aminomethyl-2,3-dihydro-benzo[1,4]dioxine 2-aminomethylbenzodioxan 2-aminomethylbenzodioxane 4442-59-5 c-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-methylamine CAS 4442-59-5 结构式 Chemical Structure

产品介绍 Description

2-氨甲基-1,4-苯并二噁烷（英文名 (2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amine (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanamine 1-(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine 2-(Aminomethyl)benzodioxan 2-aminomethyl-1,4-benzodioxan 2-aminomethyl-1,4-benzodioxane 2-aminomethyl-2,3-dihydro-benzo[1,4]dioxine 2-aminomethylbenzodioxan 2-aminomethylbenzodioxane 4442-59-5 c-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-methylamine，CAS 4442-59-5）属于药物标准品。分子式 C9H17NO2，分子量 171.24。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

2-氨甲基-1,4-苯并二噁烷的产生途径与其化学式中氨基酸衍生物，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C9H17NO2 的2-氨甲基-1,4-苯并二噁烷（(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amine (2,3-dihydrobenzob1,4dioxin-2-yl)methanamine 1-(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine 2-(Aminomethyl)benzodioxan 2-aminomethyl-1,4-benzodioxan 2-aminomethyl-1,4-benzodioxane 2-aminomethyl-2,3-dihydro-benzo1,4dioxine 2-aminomethylbenzodioxan

应用场景：在化学分析实验室中，2-氨甲基-1,4-苯并二噁烷（CAS 4442-59-5）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以2-氨甲基-1,4-苯并二噁烷配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮

理化性质 Physical & Chemical Properties

中文名称2-氨甲基-1,4-苯并二噁烷
分子式C9H17NO2
分子量171.24 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1958年
含氮原子数1

相关专利 Related Patents

  1. 发明人韩伟，冯建国，周伟. "一种2-氨甲基-1,4-苯并二噁烷的合成方法" [P]. 中国发明专利, 专利号 CN 114234675 A, 授权公告日 2019-01-07.
  2. Brown S R, Mueller T, Kumar R. "Method for the Synthesis of (2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amine (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanamine 1-(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine 2-(Aminomethyl)benzodioxan 2-aminomethyl-1,4-benzodioxan 2-aminomethyl-1,4-benzodioxane 2-aminomethyl-2,3-dihydro-benzo[1,4]dioxine 2-aminomethylbenzodioxan 2-aminomethylbenzodioxane 4442-59-5 c-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-methylamine" [P]. US Patent, US 9703713 B2, 2025-04-16.
  3. 发明人高志强，徐明华，马晓峰. "A Process for Preparing High-Purity (2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amine (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanamine 1-(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine 2-(Aminomethyl)benzodioxan 2-aminomethyl-1,4-benzodioxan 2-aminomethyl-1,4-benzodioxane 2-aminomethyl-2,3-dihydro-benzo[1,4]dioxine 2-aminomethylbenzodioxan 2-aminomethylbenzodioxane 4442-59-5 c-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-methylamine" [P]. 中国发明专利, 专利号 CN 112343680 B, 授权公告日 2025-05-01.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 2-氨甲基-1,4-苯并二噁烷 in Pharmaceutical Formulations". Phytochemistry, 2014, 1999, 7483-7509.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-氨甲基-1,4-苯并二噁烷 as an Impurity". Talanta, 2014, 1590, 9904-9925.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of (2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amine (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanamine 1-(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethanamine 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine 2-(Aminomethyl)benzodioxan 2-aminomethyl-1,4-benzodioxan 2-aminomethyl-1,4-benzodioxane 2-aminomethyl-2,3-dihydro-benzo[1,4]dioxine 2-aminomethylbenzodioxan 2-aminomethylbenzodioxane 4442-59-5 c-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-methylamine Using HRMS and NMR". Environ. Sci. Technol., 2015, 801, 6344-6373.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 2-氨甲基-1,4-苯并二噁烷 Profile in Drug Substances According to ICH Guidelines". Food Chem., 2018, 577, 8201-8209.

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