2-氨基-4,5,6,7-四氢苯并[<I>b</I>]噻酚-3-羧酸乙酯 CAS 4506-71-2

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylic acid ethyl ester ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2-amino-3-ethoxycarbonyl-thienocyclohexane ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate benzo[b]thiophene-3-carboxylic acid, 2-amino-4,5,6,7-tetrahydro-, ethyl ester ethyl-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 2-amino-4,5,6,7-tetrahydro-benzo[b] thiophene-3-carboxylic acid ethyl ester ethyl2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 4506-71-2

纯度 97%+现货药物标准品
CAS 号4506-71-2
分子式C11H19NO2S
分子量229.34 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-氨基-4,5,6,7-四氢苯并[<I>b</I>]噻酚-3-羧酸乙酯 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylic acid ethyl ester ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2-amino-3-ethoxycarbonyl-thienocyclohexane ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate benzo[b]thiophene-3-carboxylic acid, 2-amino-4,5,6,7-tetrahydro-, ethyl ester ethyl-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 2-amino-4,5,6,7-tetrahydro-benzo[b] thiophene-3-carboxylic acid ethyl ester ethyl2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 4506-71-2 CAS 4506-71-2 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的2-氨基-4,5,6,7-四氢苯并[<I>b</I>]噻酚-3-羧酸乙酯（2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylic acid ethyl ester ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2-amino-3-ethoxycarbonyl-thienocyclohexane ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate benzo[b]thiophene-3-carboxylic acid, 2-amino-4,5,6,7-tetrahydro-, ethyl ester ethyl-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 2-amino-4,5,6,7-tetrahydro-benzo[b] thiophene-3-carboxylic acid ethyl ester ethyl2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 4506-71-2）为药物标准品，CAS 登记号 4506-71-2，分子式 C11H19NO2S，分子量 229.34。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

2-氨基-4,5,6,7-四氢苯并<I>b</I>噻酚-3-羧酸乙酯的产生途径与其化学式中酰胺类，含砜基，羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 2-氨基-4,5,6,7-四氢苯并<I>b</I>噻酚-3-羧酸乙酯（2-Amino-4,5,6,7-tetrahydrobenzobthiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydro-benzobthiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylic acid ethyl ester ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2-amino-3-ethoxycarbonyl-thienocyclohexane ethyl 2-amino-4,5,6,7-tetrahyd

应用场景：从实际应用出发，2-氨基-4,5,6,7-四氢苯并 <I>b</I> 噻酚-3-羧酸乙酯（CAS 4506-71-2）在化学分析中作为关键的基准对照物质。 推荐以2-氨基-4,5,6,7-四氢苯并 <I>b</I> 噻酚-3-羧酸乙酯配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放；

理化性质 Physical & Chemical Properties

中文名称2-氨基-4,5,6,7-四氢苯并[<I>b</I>]噻酚-3-羧酸乙酯
分子式C11H19NO2S
分子量229.34 g/mol
外观形态白色至淡黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1958年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. 发明人林芳，黄志刚，唐晓军. "一种2-氨基-4,5,6,7-四氢苯并[<I>b</I>]噻酚-3-羧酸乙酯的合成方法" [P]. 中国发明专利, 专利号 CN 113747724 A, 授权公告日 2023-11-04.
  2. Rossi M, Nowak P, Lefèvre J P. "Method for the Synthesis of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylic acid ethyl ester ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2-amino-3-ethoxycarbonyl-thienocyclohexane ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate benzo[b]thiophene-3-carboxylic acid, 2-amino-4,5,6,7-tetrahydro-, ethyl ester ethyl-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 2-amino-4,5,6,7-tetrahydro-benzo[b] thiophene-3-carboxylic acid ethyl ester ethyl2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 4506-71-2" [P]. European Patent, EP 3645838 A1, 2019-03-11.
  3. 发明人周伟，罗永刚，冯建国. "A Process for Preparing High-Purity 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylic acid ethyl ester ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2-amino-3-ethoxycarbonyl-thienocyclohexane ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate benzo[b]thiophene-3-carboxylic acid, 2-amino-4,5,6,7-tetrahydro-, ethyl ester ethyl-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 2-amino-4,5,6,7-tetrahydro-benzo[b] thiophene-3-carboxylic acid ethyl ester ethyl2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 4506-71-2" [P]. 中国发明专利, 专利号 CN 108390162 B, 授权公告日 2024-05-22.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 2-氨基-4,5,6,7-四氢苯并[<I>b</I>]噻酚-3-羧酸乙酯 in Pharmaceutical Formulations". J. Sep. Sci., 2014, 2075, 2427-2436.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-氨基-4,5,6,7-四氢苯并[<I>b</I>]噻酚-3-羧酸乙酯 as an Impurity". J. Nat. Prod., 2022, 1128, (10), 3398-3414.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylic acid ethyl ester ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2-amino-3-ethoxycarbonyl-thienocyclohexane ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate benzo[b]thiophene-3-carboxylic acid, 2-amino-4,5,6,7-tetrahydro-, ethyl ester ethyl-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 2-amino-4,5,6,7-tetrahydro-benzo[b] thiophene-3-carboxylic acid ethyl ester ethyl2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 4506-71-2 Using HRMS and NMR". J. Chromatogr. A, 2022, 585, (3), 1505-1508.

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