1,3-dimethyluracil-5-carboxaldehyde CAS 4869-46-9

1,3-DiMe-5-FormU 1,3-Dimethyl-5-formyluracil 1,3-dimethyl-2,4-dioxo-pyrimidine-5-carbaldehyde 4869-46-9 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-

纯度 97%+现货药物标准品
CAS 号4869-46-9
分子式C7H8N2O3
分子量168.15 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1,3-dimethyluracil-5-carboxaldehyde 1,3-DiMe-5-FormU 1,3-Dimethyl-5-formyluracil 1,3-dimethyl-2,4-dioxo-pyrimidine-5-carbaldehyde 4869-46-9 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo- CAS 4869-46-9 结构式 Chemical Structure

产品介绍 Description

1,3-dimethyluracil-5-carboxaldehyde（1,3-DiMe-5-FormU 1,3-Dimethyl-5-formyluracil 1,3-dimethyl-2,4-dioxo-pyrimidine-5-carbaldehyde 4869-46-9 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-，CAS 号 4869-46-9）是 CATO 佳途自主生产的药物标准品，分子式 C7H8N2O3，分子量 168.15。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，1,3-dimethyluracil-5-carboxaldehyde的分子量为168.15 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 1,3-dimethyluracil-5-carboxaldehyde（1,3-DiMe-5-FormU 1,3-Dimethyl-5-formyluracil 1,3-dimethyl-2,4-dioxo-pyrimidine-5-carbaldehyde 4869-46-9 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-），CAS注册编号 4869-46-9，化学分子式为 C7H8N2O3，分子量 168.15 g/mol。 1,3-dimethyluracil-5-carboxaldehyde（C7H8N2O3）含有氨基酸衍生物，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。含氮官能团的存在使该化合物在ESI正离子模式

应用场景：1,3-dimethyluracil-5-carboxaldehyde（1,3-DiMe-5-FormU 1,3-Dimethyl-5-formyluracil 1,3-dimethyl-2,4-dioxo-pyrimidine-5-carbaldehyde 4869-46-9 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-，CAS 4869-46-9）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以1,3-dimethyluracil-5-carboxaldehyde配制标准系列工作溶液，

理化性质 Physical & Chemical Properties

中文名称1,3-dimethyluracil-5-carboxaldehyde
分子式C7H8N2O3
分子量168.15 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1958年
含氮原子数2

相关专利 Related Patents

  1. Kowalski A, Nowak P, Martínez F. "一种1,3-dimethyluracil-5-carboxaldehyde的合成方法" [P]. European Patent, EP 3474695 A1, 2019-01-15.
  2. 发明人黄志刚，罗永刚，郑宇鹏. "Method for the Synthesis of 1,3-DiMe-5-FormU 1,3-Dimethyl-5-formyluracil 1,3-dimethyl-2,4-dioxo-pyrimidine-5-carbaldehyde 4869-46-9 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-" [P]. 中国发明专利, 专利号 CN 114182838 A, 授权公告日 2015-09-01.
  3. 发明人李文辉，黄志刚，胡光. "A Process for Preparing High-Purity 1,3-DiMe-5-FormU 1,3-Dimethyl-5-formyluracil 1,3-dimethyl-2,4-dioxo-pyrimidine-5-carbaldehyde 4869-46-9 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-" [P]. 中国发明专利, 专利号 CN 108416120 B, 授权公告日 2015-03-04.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 1,3-dimethyluracil-5-carboxaldehyde in Pharmaceutical Formulations". Anal. Methods, 2019, 878, (10), 7891-7898.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1,3-dimethyluracil-5-carboxaldehyde as an Impurity". Rapid Commun. Mass Spectrom., 2016, 313, (9), 6326-6345.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 1,3-DiMe-5-FormU 1,3-Dimethyl-5-formyluracil 1,3-dimethyl-2,4-dioxo-pyrimidine-5-carbaldehyde 4869-46-9 5-Pyrimidinecarboxaldehyde, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo- Using HRMS and NMR". J. Pharm. Biomed. Anal., 2012, 1712, (5), 4588-4596.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 1,3-dimethyluracil-5-carboxaldehyde Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2010, 1007, 5360-5369.

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