(<I>S</I>)-(+)-苄基(3,5-二氧杂-4-磷杂-环庚[2,1-a;3,4-a′]二萘-4-基)甲胺 CAS 490023-37-5

(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine 490023-37-5 (+)-N-BENZYL-N-METHYL-DINAPHTHO[2,1-D:1',2']DIOXAPHOSPHEPIN-4-AMINE, (11BS);(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-BENZYL(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)METHYLAMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine SC11360

纯度 97%+现货药物标准品
CAS 号490023-37-5
分子式C28H48NO2P
分子量461.66 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-(+)-苄基(3,5-二氧杂-4-磷杂-环庚[2,1-a;3,4-a′]二萘-4-基)甲胺 (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine 490023-37-5 (+)-N-BENZYL-N-METHYL-DINAPHTHO[2,1-D:1',2']DIOXAPHOSPHEPIN-4-AMINE, (11BS);(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-BENZYL(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)METHYLAMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine SC11360 CAS 490023-37-5 结构式 Chemical Structure

产品介绍 Description

(<I>S</I>)-(+)-苄基(3,5-二氧杂-4-磷杂-环庚[2,1-a;3,4-a′]二萘-4-基)甲胺（英文名 (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine 490023-37-5 (+)-N-BENZYL-N-METHYL-DINAPHTHO[2,1-D:1',2']DIOXAPHOSPHEPIN-4-AMINE, (11BS);(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-BENZYL(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)METHYLAMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine SC11360，CAS 490023-37-5）属于药物标准品。分子式 C28H48NO2P，分子量 461.66。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 CAS编号 490023-37-5 对应的化合物(<I>S</I>)-(+)-苄基(3,5-二氧杂-4-磷杂-环庚2,1-a;3,4-a′二萘-4-基)甲胺（英文标识 (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta2,1-a;3,4-a'dinaphthalen-4-yl)benzyl(methyl)amine 490023-37-5 (+)-N-BENZYL-N-METHYL-DINAPHTHO2,1-D:1',2'DIOXAPHOSPHEPIN-4-AMINE, (11BS);(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA2,1-A3,4-A'DINAPHTHALEN-4-YL)BEN

应用场景：针对化学分析用途，(<I>S</I>)-(+)-苄基(3,5-二氧杂-4-磷杂-环庚 2,1-a;3,4-a′ 二萘-4-基)甲胺（(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta 2,1-a;3,4-a' dinaphthalen-4-yl)benzyl(methyl)amine 490023-37-5 (+)-N-BENZYL-N-METHYL-DINAPHTHO 2,1-D:1',2' DIOXAPHOSPHEPIN-4-AMINE, (11BS);(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA 2,1-A3,4-A' DIN

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-(+)-苄基(3,5-二氧杂-4-磷杂-环庚[2,1-a;3,4-a′]二萘-4-基)甲胺
分子式C28H48NO2P
分子量461.66 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数1

相关专利 Related Patents

  1. Yamamoto T, Klinger H, Brown S R. "一种(<I>S</I>)-(+)-苄基(3,5-二氧杂-4-磷杂-环庚[2,1-a;3,4-a′]二萘-4-基)甲胺的合成方法" [P]. US Patent, US 9478668 B2, 2015-12-27.
  2. 发明人郑宇鹏，马晓峰，朱建伟. "Method for the Synthesis of (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine 490023-37-5 (+)-N-BENZYL-N-METHYL-DINAPHTHO[2,1-D:1',2']DIOXAPHOSPHEPIN-4-AMINE, (11BS);(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-BENZYL(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)METHYLAMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine SC11360" [P]. 中国发明专利, 专利号 CN 114819319 A, 授权公告日 2020-04-13.
  3. 发明人林芳，王建平，郭海燕. "A Process for Preparing High-Purity (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine 490023-37-5 (+)-N-BENZYL-N-METHYL-DINAPHTHO[2,1-D:1',2']DIOXAPHOSPHEPIN-4-AMINE, (11BS);(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-BENZYL(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)METHYLAMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine SC11360" [P]. 中国发明专利, 专利号 CN 112662598 B, 授权公告日 2022-02-05.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-(+)-苄基(3,5-二氧杂-4-磷杂-环庚[2,1-a;3,4-a′]二萘-4-基)甲胺 in Pharmaceutical Formulations". J. Chromatogr. A, 2020, 1997, (10), 5603-5621.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-(+)-苄基(3,5-二氧杂-4-磷杂-环庚[2,1-a;3,4-a′]二萘-4-基)甲胺 as an Impurity". Food Chem., 2020, 255, (8), 8234-8241.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of (S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine 490023-37-5 (+)-N-BENZYL-N-METHYL-DINAPHTHO[2,1-D:1',2']DIOXAPHOSPHEPIN-4-AMINE, (11BS);(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)BENZYL(METHYL)AMINE;(S)-(+)-BENZYL(3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)METHYLAMINE;(S)-(+)-(3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)benzyl(methyl)amine SC11360 Using HRMS and NMR". Environ. Sci. Technol., 2022, 1995, 378-387.

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