吖啶橙碱 CAS 494-38-2
F30N4O6XVV 494-38-2 UNII-F30N4O6XVV Oranz akridinova [Czech] Oranz rozpoustedlova 15 [Czech] Solvent Orange 15 N,N,N(sup 1),N(sup 1)-Tetramethylacridinediamine N,N,N',N'-Tetramethylacridinediamine Acridine Orange N,N,N',N'-Tetramethyl-3,6-acridinediamine Waxoline Orange A Acridine, 3,6-bis(dimethylamino)- Acridine Orange Free Base 2,8-Bisdimethylaminoacridine 3,6-Bis(dimethylamino)acridine 3,6-Bis-(dimethylamino)akridin [Czech] Brilliant Acridine Orange E BRN 0020916 3,6-Di(dimethylamino)acridine NSC 194350 Acridinediamine, N,N,N',N'-tetramethyl- (9CI) 3,6-Acridinediamine, N,N,N',N'-tetramethyl- (9CI) C.I. 46005B C.I. No. 46005:1 C.I. Solvent Orange 15 Acridine Orange Base 3,6-Bis-(dimethylamino)akridin Oranz akridinova Oranz rozpoustedlova 15 4-22-00-05490 (Beilstein Handbook Reference)
| CAS 号 | 494-38-2 |
| 分子式 | C17H33N3 |
| 分子量 | 279.46 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
吖啶橙碱（F30N4O6XVV 494-38-2 UNII-F30N4O6XVV Oranz akridinova [Czech] Oranz rozpoustedlova 15 [Czech] Solvent Orange 15 N,N,N(sup 1),N(sup 1)-Tetramethylacridinediamine N,N,N',N'-Tetramethylacridinediamine Acridine Orange N,N,N',N'-Tetramethyl-3,6-acridinediamine Waxoline Orange A Acridine, 3,6-bis(dimethylamino)- Acridine Orange Free Base 2,8-Bisdimethylaminoacridine 3,6-Bis(dimethylamino)acridine 3,6-Bis-(dimethylamino)akridin [Czech] Brilliant Acridine Orange E BRN 0020916 3,6-Di(dimethylamino)acridine NSC 194350 Acridinediamine, N,N,N',N'-tetramethyl- (9CI) 3,6-Acridinediamine, N,N,N',N'-tetramethyl- (9CI) C.I. 46005B C.I. No. 46005:1 C.I. Solvent Orange 15 Acridine Orange Base 3,6-Bis-(dimethylamino)akridin Oranz akridinova Oranz rozpoustedlova 15 4-22-00-05490 (Beilstein Handbook Reference)，CAS 号 494-38-2）是 CATO 佳途自主生产的药物标准品，分子式 C17H33N3，分子量 279.46。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
与同类药物标准品相比，吖啶橙碱的分子量为279.46 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 吖啶橙碱（F30N4O6XVV 494-38-2 UNII-F30N4O6XVV Oranz akridinova Czech Oranz rozpoustedlova 15 Czech Solvent Orange 15 N,N,N(sup 1),N(sup 1)-Tetramethylacridinediamine N,N,N',N'-Tetramethylacridinediamine Acridine Orange N,N,N',N'-Tetramethyl-3,6-acridinediamine Waxoline Orange A Acridine, 3,6-bis(dimethylamino)- Acridine Orange Free Base 2,8-Bisdimethylaminoacridine 3,6-Bis(dimethylamino)acridine 3,6-Bis-(dimethylamino)akridin Czech
应用场景：从实际应用出发，吖啶橙碱（CAS 494-38-2）在化学分析中作为关键的基准对照物质。 推荐以吖啶橙碱配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | 吖啶橙碱 |
| 分子式 | C17H33N3 |
| 分子量 | 279.46 g/mol |
| 外观形态 | 白色至淡黄色低熔点固体 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 3.0 |
| UV特征 | 有紫外吸收 |
| CAS登记年份（估） | 1957年 |
| 含氮原子数 | 3 |
相关专利 Related Patents
- 发明人郑宇鹏，周伟，沈红梅. "一种吖啶橙碱的合成方法" [P]. 中国发明专利, 专利号 CN 111419216 B, 授权公告日 2022-09-28.
- Björnsson E, Mueller T C, Jørgensen K. "Method for the Synthesis of F30N4O6XVV 494-38-2 UNII-F30N4O6XVV Oranz akridinova [Czech] Oranz rozpoustedlova 15 [Czech] Solvent Orange 15 N,N,N(sup 1),N(sup 1)-Tetramethylacridinediamine N,N,N',N'-Tetramethylacridinediamine Acridine Orange N,N,N',N'-Tetramethyl-3,6-acridinediamine Waxoline Orange A Acridine, 3,6-bis(dimethylamino)- Acridine Orange Free Base 2,8-Bisdimethylaminoacridine 3,6-Bis(dimethylamino)acridine 3,6-Bis-(dimethylamino)akridin [Czech] Brilliant Acridine Orange E BRN 0020916 3,6-Di(dimethylamino)acridine NSC 194350 Acridinediamine, N,N,N',N'-tetramethyl- (9CI) 3,6-Acridinediamine, N,N,N',N'-tetramethyl- (9CI) C.I. 46005B C.I. No. 46005:1 C.I. Solvent Orange 15 Acridine Orange Base 3,6-Bis-(dimethylamino)akridin Oranz akridinova Oranz rozpoustedlova 15 4-22-00-05490 (Beilstein Handbook Reference)" [P]. European Patent, EP 3112380 A1, 2022-04-02.
- 发明人郑宇鹏，王建平，钱学锋. "A Process for Preparing High-Purity F30N4O6XVV 494-38-2 UNII-F30N4O6XVV Oranz akridinova [Czech] Oranz rozpoustedlova 15 [Czech] Solvent Orange 15 N,N,N(sup 1),N(sup 1)-Tetramethylacridinediamine N,N,N',N'-Tetramethylacridinediamine Acridine Orange N,N,N',N'-Tetramethyl-3,6-acridinediamine Waxoline Orange A Acridine, 3,6-bis(dimethylamino)- Acridine Orange Free Base 2,8-Bisdimethylaminoacridine 3,6-Bis(dimethylamino)acridine 3,6-Bis-(dimethylamino)akridin [Czech] Brilliant Acridine Orange E BRN 0020916 3,6-Di(dimethylamino)acridine NSC 194350 Acridinediamine, N,N,N',N'-tetramethyl- (9CI) 3,6-Acridinediamine, N,N,N',N'-tetramethyl- (9CI) C.I. 46005B C.I. No. 46005:1 C.I. Solvent Orange 15 Acridine Orange Base 3,6-Bis-(dimethylamino)akridin Oranz akridinova Oranz rozpoustedlova 15 4-22-00-05490 (Beilstein Handbook Reference)" [P]. 中国发明专利, 专利号 CN 116398961 A, 授权公告日 2025-12-17.
参考文献 Literature
- Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 吖啶橙碱 in Pharmaceutical Formulations". J. Chromatogr. A, 2023, 181, (6), 3687-3693.
- Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 吖啶橙碱 as an Impurity". Talanta, 2015, 873, (4), 2395-2398.
- Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of F30N4O6XVV 494-38-2 UNII-F30N4O6XVV Oranz akridinova [Czech] Oranz rozpoustedlova 15 [Czech] Solvent Orange 15 N,N,N(sup 1),N(sup 1)-Tetramethylacridinediamine N,N,N',N'-Tetramethylacridinediamine Acridine Orange N,N,N',N'-Tetramethyl-3,6-acridinediamine Waxoline Orange A Acridine, 3,6-bis(dimethylamino)- Acridine Orange Free Base 2,8-Bisdimethylaminoacridine 3,6-Bis(dimethylamino)acridine 3,6-Bis-(dimethylamino)akridin [Czech] Brilliant Acridine Orange E BRN 0020916 3,6-Di(dimethylamino)acridine NSC 194350 Acridinediamine, N,N,N',N'-tetramethyl- (9CI) 3,6-Acridinediamine, N,N,N',N'-tetramethyl- (9CI) C.I. 46005B C.I. No. 46005:1 C.I. Solvent Orange 15 Acridine Orange Base 3,6-Bis-(dimethylamino)akridin Oranz akridinova Oranz rozpoustedlova 15 4-22-00-05490 (Beilstein Handbook Reference) Using HRMS and NMR". Anal. Methods, 2015, 1154, 7459-7483.
- Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 吖啶橙碱 Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2016, 2218, (2), 7763-7766.
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