ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate CAS 497091-41-5

ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate

纯度 97%+现货药物标准品
CAS 号497091-41-5
分子式C17H18ClNO3S
分子量351.85 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate CAS 497091-41-5 结构式 Chemical Structure

产品介绍 Description

ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate（ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate，CAS 号 497091-41-5）是 CATO 佳途自主生产的药物标准品，分子式 C17H18ClNO3S，分子量 351.85。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

ethyl 2-(3-chloropropanoyl)amino-5-methyl-4-phenylthiophene-3-carboxylate的产生途径与其化学式中甾体骨架，酰胺类，含砜基，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 ethyl 2-(3-chloropropanoyl)amino-5-methyl-4-phenylthiophene-3-carboxylate（ethyl 2-(3-chloropropanoyl)amino-5-methyl-4-phenylthiophene-3-carboxylate），CAS注册编号 497091-41-5，化学分子式为 C17H18ClNO3S，分子量 351.85 g/mol。 从化学结构特征来看，ethyl 2-(3-chloropropanoyl)amino-5-methyl-4-phenylthiophene-3-carboxylate的分子骨架中包含甾体骨架，酰胺类，含砜基，含羟基，含醚键，含氯取代。该化合物的不饱和度为9.0，表明结构中存在

应用场景：从实际应用出发，ethyl 2- (3-chloropropanoyl)amino -5-methyl-4-phenylthiophene-3-carboxylate（CAS 497091-41-5）在化学分析中作为关键的基准对照物质。 推荐以ethyl 2- (3-chloropropanoyl)amino -5-methyl-4-phenylthiophene-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟

理化性质 Physical & Chemical Properties

中文名称ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate
分子式C17H18ClNO3S
分子量351.85 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
卤素含量Cl取代
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. Davis P L, O'Brien P Q, Park J H. "一种ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate的合成方法" [P]. US Patent, US 11843513 B2, 2020-02-09.
  2. 发明人韩伟，周伟，罗永刚. "Method for the Synthesis of ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate" [P]. 中国发明专利, 专利号 CN 114300682 A, 授权公告日 2022-06-23.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate in Pharmaceutical Formulations". Sci. Total Environ., 2013, 1033, (4), 8771-8800.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate as an Impurity". Rapid Commun. Mass Spectrom., 2016, 1558, 6500-6523.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of ethyl 2-[(3-chloropropanoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate Using HRMS and NMR". J. Pharm. Biomed. Anal., 2024, 1141, (4), 3642-3653.

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