(<I>S</I>)-SIPHOS-PE CAS 500997-70-6

(11aS)-(-)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1 inverted exclamation marka, 7 inverted exclamation marka-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine; N-Di[(R)-1-phenylethyl]-[(S)-1,1 inverted exclamation marka-spirobiindane-7,7 inverted exclamation marka-diyl]-phosphoramidite 500997-70-6 AB1005810

纯度 97%+现货药物标准品
CAS 号500997-70-6
分子式C33H56NO2P
分子量529.78 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-SIPHOS-PE (11aS)-(-)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1 inverted exclamation marka, 7 inverted exclamation marka-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine; N-Di[(R)-1-phenylethyl]-[(S)-1,1 inverted exclamation marka-spirobiindane-7,7 inverted exclamation marka-diyl]-phosphoramidite 500997-70-6 AB1005810 CAS 500997-70-6 结构式 Chemical Structure

产品介绍 Description

CAS 500997-70-6 对应的(<I>S</I>)-SIPHOS-PE（(11aS)-(-)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1 inverted exclamation marka, 7 inverted exclamation marka-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine; N-Di[(R)-1-phenylethyl]-[(S)-1,1 inverted exclamation marka-spirobiindane-7,7 inverted exclamation marka-diyl]-phosphoramidite 500997-70-6 AB1005810）为 CATO 佳途药物标准品产品线成员。分子式 C33H56NO2P，分子量 529.78。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

依据分子式为 C33H56NO2P 的(<I>S</I>)-SIPHOS-PE结构特征，其分子内含含氮杂环结构，酰胺类，有机磷，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 529.78 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 化学式为 C33H56NO2P 的(<I>S</I>)-SIPHOS-PE（(11aS)-(-)-10,11,12,13-Tetrahydrodiindeno7,1-de:1 inverted exclamation marka, 7 inverted exclamation marka-fg1,3,2dioxaphosphocin-5-bis(R)-1-phenylethylamine; N-Di(R)-1-phenylethyl-(S)-1,1 inverted exclamation marka-spirobiindane-7,7 inverted exclamation marka-di

应用场景：针对化学分析用途，(<I>S</I>)-SIPHOS-PE（(11aS)-(-)-10,11,12,13-Tetrahydrodiindeno 7,1-de:1 inverted exclamation marka, 7 inverted exclamation marka-fg 1,3,2 dioxaphosphocin-5-bis (R)-1-phenylethyl amine; N-Di (R)-1-phenylethyl - (S)-1,1 inverted exclamation marka-spirobiindane-7,7 inverted exclamation marka-

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-SIPHOS-PE
分子式C33H56NO2P
分子量529.78 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1984年
含氮原子数1

相关专利 Related Patents

  1. 发明人钱学锋，朱建伟，徐明华. "一种(<I>S</I>)-SIPHOS-PE的合成方法" [P]. 中国发明专利, 专利号 CN 110444637 A, 授权公告日 2020-09-08.
  2. 发明人赵玉洁，郭海燕，罗永刚. "Method for the Synthesis of (11aS)-(-)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1 inverted exclamation marka, 7 inverted exclamation marka-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine; N-Di[(R)-1-phenylethyl]-[(S)-1,1 inverted exclamation marka-spirobiindane-7,7 inverted exclamation marka-diyl]-phosphoramidite 500997-70-6 AB1005810" [P]. 中国发明专利, 专利号 CN 109028322 A, 授权公告日 2021-04-16.
  3. O'Brien P Q, Johnson M A, Klinger H. "A Process for Preparing High-Purity (11aS)-(-)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1 inverted exclamation marka, 7 inverted exclamation marka-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine; N-Di[(R)-1-phenylethyl]-[(S)-1,1 inverted exclamation marka-spirobiindane-7,7 inverted exclamation marka-diyl]-phosphoramidite 500997-70-6 AB1005810" [P]. US Patent, US 11196452 B2, 2015-10-27.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-SIPHOS-PE in Pharmaceutical Formulations". J. Sep. Sci., 2022, 1106, (4), 7962-7986.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-SIPHOS-PE as an Impurity". Anal. Methods, 2012, 1085, (3), 7747-7764.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of (11aS)-(-)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1 inverted exclamation marka, 7 inverted exclamation marka-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine; N-Di[(R)-1-phenylethyl]-[(S)-1,1 inverted exclamation marka-spirobiindane-7,7 inverted exclamation marka-diyl]-phosphoramidite 500997-70-6 AB1005810 Using HRMS and NMR". Anal. Chim. Acta, 2015, 618, 6334-6363.

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