10:0（3-氧代）辅酶A CAS 50411-91-1

50411-91-1 CTK4J2581 S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-HYDROXY-3-PHOSPHONOOXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL]OXY-HYDROXYPHOSPHORYL]OXY-2-HYDROXY-3,3-DIMETHYLBUTANOYL]AMINO]PROPANOYLAMINO]ETHYL] 3-OXODECANETHIOATE

纯度 97%+现货药物标准品
CAS 号50411-91-1
分子式C31H49N7O18P3S 3*H4N
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

10:0（3-氧代）辅酶A 50411-91-1 CTK4J2581 S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-HYDROXY-3-PHOSPHONOOXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL]OXY-HYDROXYPHOSPHORYL]OXY-2-HYDROXY-3,3-DIMETHYLBUTANOYL]AMINO]PROPANOYLAMINO]ETHYL] 3-OXODECANETHIOATE CAS 50411-91-1 结构式 Chemical Structure

产品介绍 Description

10:0（3-氧代）辅酶A（50411-91-1 CTK4J2581 S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-HYDROXY-3-PHOSPHONOOXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL]OXY-HYDROXYPHOSPHORYL]OXY-2-HYDROXY-3,3-DIMETHYLBUTANOYL]AMINO]PROPANOYLAMINO]ETHYL] 3-OXODECANETHIOATE）是药物分析与质量控制领域常用的药物标准品，CAS 号 50411-91-1。分子式 C31H49N7O18P3S 3*H4N。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

作为认证标准物质（CRM），10:0（3-氧代）辅酶A满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 CAS编号 50411-91-1 对应的化合物10:0（3-氧代）辅酶A（英文标识 50411-91-1 CTK4J2581 S-2-3-4-(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-HYDROXY-3-PHOSPHONOOXYOXOLAN-2-YLMETHOXY-HYDROXYPHOSPHORYLOXY-HYDROXYPHOSPHORYLOXY-2-HYDROXY-3,3-DIMETHYLBUTANOYLAMINOPROPANOYLAMINOETHYL 3-OXODECANETHIOATE），化学式 C31H49N7O18P3S 3H4N，相对分子质量 950.78。 10:0（3-氧代）辅酶A（C31H49N7O18P3S 3H4N）含有含氮杂环结构，酰胺类，含砜基，含磷酸

应用场景：针对化学分析用途，10:0（3-氧代）辅酶A（50411-91-1 CTK4J2581 S- 2- 3- 4- (2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-HYDROXY-3-PHOSPHONOOXYOXOLAN-2-YL METHOXY-HYDROXYPHOSPHORYL OXY-HYDROXYPHOSPHORYL OXY-2-HYDROXY-3,3-DIMETHYLBUTANOYL AMINO PROPANOYLAMINO ETHYL 3-OXODECANETHIOATE）是具有明确定量溯源的认证级对照品。 推荐以10:0（3-氧代）辅酶A配制标准

理化性质 Physical & Chemical Properties

中文名称10:0（3-氧代）辅酶A
分子式C31H49N7O18P3S 3*H4N
分子量950.78 g/mol
外观形态淡黄色至黄色无定形粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1971年
含氮原子数8
含硫原子数1

相关专利 Related Patents

  1. 发明人罗永刚，陈志强，徐明华. "一种10:0（3-氧代）辅酶A的合成方法" [P]. 中国发明专利, 专利号 CN 114790637 B, 授权公告日 2024-03-02.
  2. 发明人唐晓军，朱建伟，孙丽萍. "Method for the Synthesis of 50411-91-1 CTK4J2581 S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-HYDROXY-3-PHOSPHONOOXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL]OXY-HYDROXYPHOSPHORYL]OXY-2-HYDROXY-3,3-DIMETHYLBUTANOYL]AMINO]PROPANOYLAMINO]ETHYL] 3-OXODECANETHIOATE" [P]. 中国发明专利, 专利号 CN 115723084 B, 授权公告日 2022-05-06.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 10:0（3-氧代）辅酶A in Pharmaceutical Formulations". Chromatographia, 2010, 898, (7), 7500-7508.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 10:0（3-氧代）辅酶A as an Impurity". Environ. Sci. Technol., 2018, 1256, 4860-4878.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 50411-91-1 CTK4J2581 S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-HYDROXY-3-PHOSPHONOOXYOXOLAN-2-YL]METHOXY-HYDROXYPHOSPHORYL]OXY-HYDROXYPHOSPHORYL]OXY-2-HYDROXY-3,3-DIMETHYLBUTANOYL]AMINO]PROPANOYLAMINO]ETHYL] 3-OXODECANETHIOATE Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2014, 1599, 1071-1092.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 10:0（3-氧代）辅酶A Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2021, 1323, (11), 5472-5479.

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