<I>n </I>-十二烷基膦酸 CAS 5137-70-2

5137-70-2 Dodecylphosphonic acid Phosphonic acid, dodecyl- Phosphonic acid, P-dodecyl- 4-04-00-03565 (Beilstein Handbook Reference) BRN 1778341 Dodecane phosphonic acid n-Dodecanephosphonic acid 1-Dodecanephosphonic acid n-Dodecyl phosphonic acid n-Dodecylphosphonic acid EINECS 225-897-8 NSC 407872

纯度 97%+现货药物标准品
CAS 号5137-70-2
分子式C12H27O3P
分子量250.31 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

<I>n </I>-十二烷基膦酸 5137-70-2 Dodecylphosphonic acid Phosphonic acid, dodecyl- Phosphonic acid, P-dodecyl- 4-04-00-03565 (Beilstein Handbook Reference) BRN 1778341 Dodecane phosphonic acid n-Dodecanephosphonic acid 1-Dodecanephosphonic acid n-Dodecyl phosphonic acid n-Dodecylphosphonic acid EINECS 225-897-8 NSC 407872 CAS 5137-70-2 结构式 Chemical Structure

产品介绍 Description

<I>n </I>-十二烷基膦酸（5137-70-2 Dodecylphosphonic acid Phosphonic acid, dodecyl- Phosphonic acid, P-dodecyl- 4-04-00-03565 (Beilstein Handbook Reference) BRN 1778341 Dodecane phosphonic acid n-Dodecanephosphonic acid 1-Dodecanephosphonic acid n-Dodecyl phosphonic acid n-Dodecylphosphonic acid EINECS 225-897-8 NSC 407872，CAS 号 5137-70-2）是 CATO 佳途自主生产的药物标准品，分子式 C12H27O3P，分子量 250.31。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

CAS编号 5137-70-2 对应的化合物<I>n </I>-十二烷基膦酸（英文标识 5137-70-2 Dodecylphosphonic acid Phosphonic acid, dodecyl- Phosphonic acid, P-dodecyl- 4-04-00-03565 (Beilstein Handbook Reference) BRN 1778341 Dodecane phosphonic acid n-Dodecanephosphonic acid 1-Dodecanephosphonic acid n-Dodecyl phosphonic acid n-Dodecylphosphonic acid EINECS 225-897-8 NSC 407872），化学式 C12H27O3P，相对分子质量 250.31。 <I>n </I>-十二烷基膦酸（分子式 C12H27O3P）的化学结构中包含含膦酸基，羧酸类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP）影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。由于碳链

应用场景：针对化学分析用途，<I>n </I>-十二烷基膦酸（5137-70-2 Dodecylphosphonic acid Phosphonic acid, dodecyl- Phosphonic acid, P-dodecyl- 4-04-00-03565 (Beilstein Handbook Reference) BRN 1778341 Dodecane phosphonic acid n-Dodecanephosphonic acid 1-Dodecanephosphonic acid n-Dodecyl phosphonic acid n-Dodecylphosphonic acid EI

理化性质 Physical & Chemical Properties

中文名称<I>n </I>-十二烷基膦酸
分子式C12H27O3P
分子量250.31 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）-0.5
CAS登记年份（估）1958年

相关专利 Related Patents

  1. Martínez F, Nielsen H, Mueller T C. "一种<I>n </I>-十二烷基膦酸的合成方法" [P]. European Patent, EP 3626005 A1, 2018-03-05.
  2. 发明人朱建伟，胡光，沈红梅. "Method for the Synthesis of 5137-70-2 Dodecylphosphonic acid Phosphonic acid, dodecyl- Phosphonic acid, P-dodecyl- 4-04-00-03565 (Beilstein Handbook Reference) BRN 1778341 Dodecane phosphonic acid n-Dodecanephosphonic acid 1-Dodecanephosphonic acid n-Dodecyl phosphonic acid n-Dodecylphosphonic acid EINECS 225-897-8 NSC 407872" [P]. 中国发明专利, 专利号 CN 108631881 A, 授权公告日 2016-11-02.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of <I>n </I>-十二烷基膦酸 in Pharmaceutical Formulations". Anal. Chim. Acta, 2024, 2359, 5989-6019.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>n </I>-十二烷基膦酸 as an Impurity". Biomed. Chromatogr., 2012, 1026, 3074-3101.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 5137-70-2 Dodecylphosphonic acid Phosphonic acid, dodecyl- Phosphonic acid, P-dodecyl- 4-04-00-03565 (Beilstein Handbook Reference) BRN 1778341 Dodecane phosphonic acid n-Dodecanephosphonic acid 1-Dodecanephosphonic acid n-Dodecyl phosphonic acid n-Dodecylphosphonic acid EINECS 225-897-8 NSC 407872 Using HRMS and NMR". Sci. Total Environ., 2010, 93, 8484-8498.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate <I>n </I>-十二烷基膦酸 Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2010, 1735, (4), 8858-8879.

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