(1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos CAS 528814-26-8

(1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-2,2 inverted exclamation marka-Di-tert-butyl-2,3,2 inverted exclamation marka,3 inverted exclamation marka-tetrahydro-1H,1 inverted exclamation markaH-(1,1 inverted exclamation marka)biisophosphindolyl (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-DuanPhos 528814-26-8

纯度 97%+现货药物标准品
CAS 号528814-26-8
分子式C24H44P2
分子量394.55 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-2,2 inverted exclamation marka-Di-tert-butyl-2,3,2 inverted exclamation marka,3 inverted exclamation marka-tetrahydro-1H,1 inverted exclamation markaH-(1,1 inverted exclamation marka)biisophosphindolyl (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-DuanPhos 528814-26-8 CAS 528814-26-8 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的(1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos（(1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-2,2 inverted exclamation marka-Di-tert-butyl-2,3,2 inverted exclamation marka,3 inverted exclamation marka-tetrahydro-1H,1 inverted exclamation markaH-(1,1 inverted exclamation marka)biisophosphindolyl (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-DuanPhos 528814-26-8）为药物标准品，CAS 登记号 528814-26-8，分子式 C24H44P2，分子量 394.55。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

(1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos的产生途径与其化学式中有机磷密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 528814-26-8 对应的化合物(1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos（英文标识 (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-2,2 inverted exclamation marka-Di-tert-butyl-2,3,2 inverted exclamation marka,3 inverted exclamation marka-tetrahydro-1H,1 inverted exclamation markaH-(1,1 inverted exclamation marka)biisophosphindolyl (1R,1 inverted exclamation markaR,2S,2 invert

应用场景：针对化学分析用途，(1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos（(1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-2,2 inverted exclamation marka-Di-tert-butyl-2,3,2 inverted exclamation marka,3 inverted exclamation marka-tetrahydro-1H,1 inverted exclamation markaH-(1,1 inverted excla

理化性质 Physical & Chemical Properties

中文名称(1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos
分子式C24H44P2
分子量394.55 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件室温保存
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1984年

相关专利 Related Patents

  1. Roberts E F, Schröder R, Klinger H. "一种(1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos的合成方法" [P]. US Patent, US 9434316 B2, 2015-02-23.
  2. Patel M V, Park J H, Stevens L M. "Method for the Synthesis of (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-2,2 inverted exclamation marka-Di-tert-butyl-2,3,2 inverted exclamation marka,3 inverted exclamation marka-tetrahydro-1H,1 inverted exclamation markaH-(1,1 inverted exclamation marka)biisophosphindolyl (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-DuanPhos 528814-26-8" [P]. US Patent, US 10827410 B2, 2018-01-18.
  3. 发明人韩伟，罗永刚，郭海燕. "A Process for Preparing High-Purity (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-2,2 inverted exclamation marka-Di-tert-butyl-2,3,2 inverted exclamation marka,3 inverted exclamation marka-tetrahydro-1H,1 inverted exclamation markaH-(1,1 inverted exclamation marka)biisophosphindolyl (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-DuanPhos 528814-26-8" [P]. 中国发明专利, 专利号 CN 116001800 A, 授权公告日 2024-01-01.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of (1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos in Pharmaceutical Formulations". Phytochemistry, 2012, 1151, (1), 7299-7302.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of (1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos as an Impurity". J. Agric. Food Chem., 2019, 983, (9), 4353-4356.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-2,2 inverted exclamation marka-Di-tert-butyl-2,3,2 inverted exclamation marka,3 inverted exclamation marka-tetrahydro-1H,1 inverted exclamation markaH-(1,1 inverted exclamation marka)biisophosphindolyl (1R,1 inverted exclamation markaR,2S,2 inverted exclamation markaS)-DuanPhos 528814-26-8 Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2025, 2269, (7), 9617-9622.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate (1<I>R</I>,1′<I>R</I>,2<I>S</I>,2′<I>S</I>)-DuanPhos Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2018, 1548, 2163-2174.

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