2-[(1′,1′,1′-三氟-2′-(三氟甲基)-2′-羧基)丙基]-3-降冰片基 甲基丙烯酸酯 CAS 824411-04-3
2-[(1 inverted exclamation marka,1 inverted exclamation marka,1 inverted exclamation marka-Trifluoro-2 inverted exclamation marka-(trifluoromethyl)-2 inverted exclamation marka-hydroxy)propyl]-3-norbornyl methacrylate 3-[3,3,3-Trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]bicyclo[2.2.1]hept-2-yl methacrylate 824411-04-3 HFA monomer
| CAS 号 | 824411-04-3 |
| 分子式 | C15H18F6O3 |
| 分子量 | 360.29 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
2-[(1′,1′,1′-三氟-2′-(三氟甲基)-2′-羧基)丙基]-3-降冰片基 甲基丙烯酸酯（英文名 2-[(1 inverted exclamation marka,1 inverted exclamation marka,1 inverted exclamation marka-Trifluoro-2 inverted exclamation marka-(trifluoromethyl)-2 inverted exclamation marka-hydroxy)propyl]-3-norbornyl methacrylate 3-[3,3,3-Trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]bicyclo[2.2.1]hept-2-yl methacrylate 824411-04-3 HFA monomer，CAS 824411-04-3）属于药物标准品。分子式 C15H18F6O3，分子量 360.29。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
2-(1′,1′,1′-三氟-2′-(三氟甲基)-2′-羧基)丙基-3-降冰片基 甲基丙烯酸酯的产生途径与其化学式中羧酸类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 2-(1′,1′,1′-三氟-2′-(三氟甲基)-2′-羧基)丙基-3-降冰片基 甲基丙烯酸酯（2-(1 inverted exclamation marka,1 inverted exclamation marka,1 inverted exclamation marka-Trifluoro-2 inverted exclamation marka-(trifluoromethyl)-2 inverted exclamation marka-hydroxy)propyl-3-norbornyl methacrylate 3-3,3,3-Trifluoro-2-hydroxy-2-(trifluoromethyl)propylbicyclo2.2.1hept-2-yl methacrylate 824411-04-3 HFA monomer），CA
应用场景：2- (1′,1′,1′-三氟-2′-(三氟甲基)-2′-羧基)丙基 -3-降冰片基 甲基丙烯酸酯（2- (1 inverted exclamation marka,1 inverted exclamation marka,1 inverted exclamation marka-Trifluoro-2 inverted exclamation marka-(trifluoromethyl)-2 inverted exclamation marka-hydroxy)propyl -3-norbornyl methacrylate 3- 3,3,3-Trifluoro-2-hydroxy-2-(
理化性质 Physical & Chemical Properties
| 中文名称 | 2-[(1′,1′,1′-三氟-2′-(三氟甲基)-2′-羧基)丙基]-3-降冰片基 甲基丙烯酸酯 |
| 分子式 | C15H18F6O3 |
| 分子量 | 360.29 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，密封防潮 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 4.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1986年 |
| 卤素含量 | F取代 |
相关专利 Related Patents
- Lee S K, Stevens L M, Yamamoto T. "一种2-[(1′,1′,1′-三氟-2′-(三氟甲基)-2′-羧基)丙基]-3-降冰片基 甲基丙烯酸酯的合成方法" [P]. US Patent, US 10324280 B2, 2023-06-17.
- 发明人李文辉，赵玉洁，钱学锋. "Method for the Synthesis of 2-[(1 inverted exclamation marka,1 inverted exclamation marka,1 inverted exclamation marka-Trifluoro-2 inverted exclamation marka-(trifluoromethyl)-2 inverted exclamation marka-hydroxy)propyl]-3-norbornyl methacrylate 3-[3,3,3-Trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]bicyclo[2.2.1]hept-2-yl methacrylate 824411-04-3 HFA monomer" [P]. 中国发明专利, 专利号 CN 114593779 A, 授权公告日 2025-05-21.
参考文献 Literature
- Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 2-[(1′,1′,1′-三氟-2′-(三氟甲基)-2′-羧基)丙基]-3-降冰片基 甲基丙烯酸酯 in Pharmaceutical Formulations". Food Chem., 2022, 809, (11), 6443-6458.
- Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-[(1′,1′,1′-三氟-2′-(三氟甲基)-2′-羧基)丙基]-3-降冰片基 甲基丙烯酸酯 as an Impurity". J. Chromatogr. A, 2024, 649, (11), 1037-1067.
- Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 2-[(1 inverted exclamation marka,1 inverted exclamation marka,1 inverted exclamation marka-Trifluoro-2 inverted exclamation marka-(trifluoromethyl)-2 inverted exclamation marka-hydroxy)propyl]-3-norbornyl methacrylate 3-[3,3,3-Trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]bicyclo[2.2.1]hept-2-yl methacrylate 824411-04-3 HFA monomer Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2010, 380, 2811-2826.
Related inverted Standards 同系列产品
- 二溴代异丁酸乙二醇酯 (CAS 248603-11-4)
- 史氏环氧化噁唑烷酮乙基催化剂 (CAS 879880-79-2)
- 4′-(4-氯苯基)-2, 2′:6′, 2″-三联吡啶 (CAS 89972-75-8)
- 179248-59-0 4-(4 inverted exclamation marka-Phenoxyanilino)-6,7-dimethoxyquinazoline 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine SKI-1 Src Inhibitor-1 Src-l1 (CAS 179248-59-0)
- 2,2′:5′,2′′:5′′,2′′′-四噻吩 (CAS 5632-29-1)
- 1081849-97-9 4,4 inverted exclamation mark -(1,5-Pentanediyldiimino)bisbenzoic Acid 4,4'-(1,5-Pentanediyldiimino)dibenzoic Acid (CAS 1081849-97-9)
- 史氏环氧化恶唑烷酮甲基催化剂 (CAS 403501-30-4)
- 5′-己基-2,2′-联噻吩-5-硼酸频哪醇酯 (CAS 579503-59-6)
推荐产品 Recommended Standards
- N-(2-(4-Bromophenyl)thiophen-3-yl)propane-2-sulfonamide (CAS 916429-85-1)
- 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-1-((2,5-dioxopyrrolidin-1-yl)oxy)-1-oxobutane-2-sulfonic acid (CAS 1193111-46-4)
- 5-(((4-Bromobenzyl)sulfinyl)methyl)-4-ethyl-4H-1,2,4-triazole-3-thiol (CAS 344274-71-1)
- (3R)-3-(propan-2-yl)morpholine (CAS 74572-01-3)
- (2E,4E)-3-Methyl-5-(4-hydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienenitrile (CAS 178938-94-8)
- 1-Methyl-3-(3-(thiophen-2-yl)propyl)-1h-pyrazol-5-amine (CAS 1152656-87-5)
- 4-(Benzylthio)-5-chloropyridine-3-sulfonamide (CAS 1352525-78-0)
- 2-((2-Chlorophenyl)sulfonyl)-1-morpholinoethan-1-one (CAS 339097-93-7)
- 8,9-Dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,2-a]quinoxalin-5-one hydrochloride (CAS 276695-22-8)
- 司美格鲁肽杂质276 (CAS CATO-C4X-2226276)
为什么选择 CATO 佳途？
- ISO 17034 / CNAS / ANAB 三重认证标准物质生产商
- 130,000+ 品种现货库存，支持 COA 定制
- 专业技术支持：+86 13829788188 / jacky.chen@cato-chem.com
- 全球 10,000+ 客户信赖之选