(<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 CAS 53101-49-8

1O8B70QB9P 53101-49-8 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (+)- UNII-1O8B70QB9P 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2R)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (R)- (+)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (R)-Trolox

纯度 97%+现货药物标准品
CAS 号53101-49-8
分子式C14H24O4
分子量256.34 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 1O8B70QB9P 53101-49-8 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (+)- UNII-1O8B70QB9P 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2R)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (R)- (+)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (R)-Trolox CAS 53101-49-8 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品(<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸（1O8B70QB9P 53101-49-8 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (+)- UNII-1O8B70QB9P 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2R)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (R)- (+)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (R)-Trolox，CAS 53101-49-8），分子式 C14H24O4，分子量 256.34。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

(<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸（C14H24O4）含有羧酸类，含羟基，含醚键。具有较强的吸湿性，较高的碳氢比使其脂溶性较好，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。较高的碳氢原子比赋予该化合物良好的脂溶性，可使用正己烷或乙酸乙酯等非极性溶剂进行液-液萃取前处理。 (<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸（1O8B70QB9P 53101-49-8 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (+)- UNII-1O8B70QB9P 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2R)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (R)- (+)-6-Hydrox

应用场景：在化学分析实验室中，(<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸（CAS 53101-49-8）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于阴凉处（≤25°C）保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，

理化性质 Physical & Chemical Properties

中文名称(<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
分子式C14H24O4
分子量256.34 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1972年

相关专利 Related Patents

  1. 发明人李文辉，王建平，黄志刚. "一种(<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸的合成方法" [P]. 中国发明专利, 专利号 CN 117676212 B, 授权公告日 2019-06-19.
  2. 发明人郑宇鹏，何建平，徐明华. "Method for the Synthesis of 1O8B70QB9P 53101-49-8 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (+)- UNII-1O8B70QB9P 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2R)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (R)- (+)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (R)-Trolox" [P]. 中国发明专利, 专利号 CN 109442644 A, 授权公告日 2022-10-11.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 in Pharmaceutical Formulations". J. Chromatogr. A, 2017, 812, (9), 5149-5165.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 as an Impurity". J. Agric. Food Chem., 2023, 1261, (5), 3648-3652.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 1O8B70QB9P 53101-49-8 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (+)- UNII-1O8B70QB9P 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (2R)- 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (R)- (+)-6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (R)-Trolox Using HRMS and NMR". Sci. Total Environ., 2019, 2191, 7135-7142.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate (<I>R</I>)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2023, 414, (11), 7244-7270.

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